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  • De Angelis G, Allignol A, Murthy A, Wolkewitz M, Beyersmann J, Safran E, Schrenzel J, Pittet D, Harbarth S.
    Multistate modelling to estimate the excess length of stay associated with meticillin-resistant Staphylococcus aureus colonisation and infection in surgical patients.
    J Hosp Infect, 2011; 78: 86-91: http://dx.doi.org/10.1016/j.jhin.2011.02.003 \
  • Graves N, Barnett AG, Halton K, Crnich C, Cooper B, Beyersmann J, Wolkewitz M, Samore M, Harbarth S.
    The Importance of Good Data, Analysis, and Interpretation for Showing the Economics of Reducing Healthcare-Associated Infection.
    /Infection Control and Hospital Epidemiology/, 2011; 32: 927-928:
  • Binder H., Porzelius C., Schumacher M.
    An overview of techniques for linking high-dimensional molecular data to time-to-event endpoints by risk prediction models.
    Biometrical Journal 53, 2011, 170-189.
  • Eugster M., Knaus J., Porzelius C., Schmidberger M., Vicedo E.
    Hands-on tutorial for parallel computing with R.
    Computational Statistics 26, 2011, 219-239.
  • Porzelius C., Johannes M., Binder H., Beißbarth T.
    Leveraging external knowledge on molecular interactions in classification methods for risk prediction of patients.
    Biometrical Journal 53, 2011, 190-201.
  • Porzelius C., Schumacher M., Binder H.
    The benefit of data-based model complexity selection via prediction error curves in time-to-event data.
    Computational Statistics 26, 2011, 293-302.
  • Binder H, Porzelius C, Schumacher M.
    An overview of techniques for linking high-dimensional molecular data to time-to-event endpoints by risk prediction models.
    Biometrical Journal, 2011; 53: 170-189.
  • Porzelius C, Johannes M, Binder H, Beißbarth T.
    Leveraging external knowledge on molecular interactions in classification methods for risk prediction of patients.
    Biometrical Journal, 2011; 53: 190-201
  • Porzelius C, Schumacher M, Binder H.
    The benefit of data-based model complexity selection via prediction error curves in time-to-event data.
    Computational Statistics, 2011; 26: 293-302
  • Rücker G, Schwarzer G, Carpenter JR, Binder H, Schumacher M.
    Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis. Biostatistics, 2011; 12: 122-142
  • Schoop R, Beyersmann J, Schumacher M, Binder H.
    Quantifying the predictive accuracy of time-to-event models in the presence of competing risks.
    Biometrical Journal, 2011; 53: 88-112
  • Bauer R, Gottfriedsen G-U, Binder H, Dobmeier M, Cording C, Hajak G, Spiessl H.
    Burden of caregivers of patients with bipolar affective disorders.
    American Journal of Orthopsychiatry, 2011; 81: 139-148.
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  • Binder H, Sauerbrei W.
    Adding local components to global functions for continuous covariates in multivariable regression modeling.
    Statistics in Medicine, 2010; 29: 800-817.
  • Porzelius C, Schumacher M, Binder H.
    A general, prediction error-based criterion for selecting model complexity for high-dimensional survival models.
    Statistics in Medicine, 2010; 29: 830-838.
  • Porzelius C, Schumacher M, Binder H.
    Sparse regression techniques in low-dimensional survival settings.
    Statistics and Computing, 2010; 20:151-163.
  • Binder H, Sauerbrei W.
    Adding local components to global functions for continuous covariates in multivariable regression modeling.
    Statistics in Medicine, 2010; 29: 800-817.
  • Porzelius C, Schumacher M, Binder H.
    A general, prediction error-based criterion for selecting model complexity for high-dimensional survival models.
    Statistics in Medicine, 2010; 29: 830-838.
  • Porzelius C, Schumacher M, Binder H.
    Sparse regression techniques in low-dimensional survival settings.
    Statistics and Computing, 2010; 20:151-163.
  • Sreseli RT, Binder H, Kuhn M, Digel W, Veelken H, Sienel W, Passlick B, Schumacher M, Martens UM, Zimmermann S.
    Identification of a 17-protein signature in the serum of lung cancer patients.
    Oncology Reports, 2010; 24:263-270
  • De Angelis G, Murthy A, Beyersmann J, Harbarth S:
    Estimating the impact of healthcare-associated infections on length of stay and
    Clin Microbiol Infec, 2010; 16: 1729-1735
  • Graves N, Harbarth S, Beyersmann J, Barnett A, Halton K, Cooper B:
    Healthcare epidemiology: estimating the cost of health care associated infections: mind your p's and q's.
    Clin Infect Dis, 2010; 50: 1017-1021
  • Zahn D, Weidner G, Beyersmann J, Smits JMA, Deng MC, Kaczmarek I,
    Meyer S, Reichenspurner H, Mehlhorn U, Wagner FM, Spaderna H:
    Composite risk scores and depression as predictors of competing
    waiting-list outcomes: the Waiting for a New Heart Study.
    Transpl Int, 2010; 23: 1223-1232
  • Zuschneid I, Rücker G, Schoop R, Beyersmann J, Schumacher M, Geffers
    C, Rüden H, Gastmeier P:
    Representativeness of the surveillance data in the intensive care unit component of the German Nosocomial Infections Surveillance System.
    Infect Cont Hosp Ep, 2010; 31: 934-938


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  • K. Wester, S. Digiuni, F. Geier, J. Timmer, C. Fleck, M. Hülskamp
    Functional diversity of R3 single-repeat genes in trichome development.
    Development 136, 2009, 1487-1496 pdf
  • N. Borisov, E. Aksamitiene, A. Kiyatkin, S. Legewie, J. Berkhout, T. Maiwald, N.P. Kaimachnikov, J. Timmer, J.B. Hoek, B.N. Kholodenko
    Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.
    Mol. Sys. Bio. 5, 2009, 256 pdf
  • T. Wiech, E. Nikolopoulos, R. Weis, R. Langer, K. Bartholome, J. Timmer, A. Walch, H. Höfler, M. Werner
    Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays.
    Laboratory Investigation 89, 2009, 385-397
  • Mammen E., Nandi S., Maiwald T., Timmer J.
    Effect of jump discontinuity for phase-randomized surrogate data testing.
    Int. J. Bif. Chaos 19, 2009, 403-408 pdf
  • B. Schelter, J. Timmer, M. Eichler
    Assessing the strength of directed influences among neural signals using renormalized partial directed coherence.
    J. Neuroscience Methods 179, 2009, 121-130 pdf
  • S. Lassmann, C. Kreutz, A. Schoepflin, U. Hopt, J. Timmer, M. Werner
    A novel approach for reliable microarray analysis of microdissected tumour cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens.
    J. Molecular Medicine 87, 2009, 211-224 pdf
  • Hellwig B., Mund P., Schelter B. Guschlbauer B., Timmer J., Lücking C.H.
    A longitudinal study of tremor frequencies in Parkinson's disease and essential tremor.
    Clinical Neurophysiology 120, 2009, 431-435 pdf
  • M. Gerstung, J. Timmer, C. Fleck
    Noisy signalling through promoter logic gates.
    Phys. Rev. E 79, 2009, 11923 pdf
  • Kreutz C., Timmer J.
    Systems biology: experimental design.
    FEBS Journal 276, 2009, 923-942 pdf
  • M. Joschko, R. Gebbers, D. Barkusky, J. Rogasik, W. Höhn, W. Hierold, C.A. Fox, J. Timmer
    Location-dependency of earthworm response to reduced tillage on sandy soil.
    Soil & Tillage Research 102, 2009, 55-66 pdf
  • Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J, Klingmüller U.
    Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions.

    Mol Syst Biol. 2009;5:334.

  • Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
    Modeling the effect of time-dependent exposure on intensive care unit mortality.
    Intens Care Med, 2009; 35: 826-832: http://dx.doi.org/10.1007/s00134-009-1423-6
  • Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
    Efficient risk set sampling when a time-dependent exposure is present. Matching for time to exposure versus exposure density sampling.
    Method Inform Med, 2009; 48: 438-443: http://dx.doi.org/10.3414/ME9241
  • Knaus J., Porzelius C., Binder H., Schwarzer G.
    Easier Parallel Computing in R with snowfall and sfCluster.
    The R Journal 1, 2009, 54-59.
  • Porzelius C., Binder H., Schumacher M.
    Parallelized prediction error estimation for evaluation of high-dimensional models.
    Bioinformatics 25, 2009, 827-829.
  • Binder H, Allignol A, Schumacher M, Beyersmann J.
    Boosting for high-dimensional time-to-event data with competing risks.
    Bioinformatics, 2009; 25: 890-896.
  • Binder, H, Graf E:
    Brier scores.
    In Kattan MW, editor, Encyclopedia of Medical Decision Making. SAGE Publications, 2009.
  • Binder H, Sauerbrei W.
    Stability analysis of an additive spline model for respiratory health data using knot removal.
    Journal of the Royal Statistical Society: Series C (Applied Statistics), 2009; 58:577-600.
  • Binder H, Schumacher M.
    Incorporating pathway information into boosting estimation of high-dimensional risk prediction models.
    BMC Bioinformatics, 2009; 10: 18.
  • Beyersmann J, Kneib T, Schumacher M, Gastmeier P:
    Nosocomial infection, length of stay, and time\u2010dependent bias.
    Infect Cont Hosp Ep, 2009; 30: 273-276
  • Beyersmann J, Latouche A, Buchholz A, Schumacher M:
    Simulating competing risks data in survival analysis.
    Stat Med, 2009; 8: 956-971
  • L. Sommerlade, M. Eichler, M. Jachan, K. Henschel, J. Timmer, B. Schelter. Estimating causal dependencies in networks of nonlinear stochastic dynamical systems.
    Phys. Rev. E 80, 2009, 051128
  • L. Sommerlade, K. Henschel, J. Wohlmuth, M. Jachan, F. Amtage, B. Hellwig, C.H. Lücking, J. Timmer, B. Schelter.
    Time-variant estimation of directed influence during Parkinsonian tremor.
    J. Physiol.103, 2009, 348-352


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  • W. Mader, D. Feess, R. Lange, D. Saur, V. Glauche, C. Weiller, J. Timmer, B. Schelter
    On the detection of direct directed information flow in fMRI.
    IEEE J. Sel. Topics in Signal Processing 2, 2008, 965-974 pdf
  • K. Henschel, B. Hellwig, F. Amtage, M. Jachan, C.H. Lücking, J. Timmer, B. Schelter
    Multivariate Analyis of dynamical processes: Point processes and time series.
    Europ. Phys. J. 165, 2008, 25-34 pdf
  • F. Geier, J.U. Lohmann, M. Gerstung, A.T. Maier, J. Timmer, C. Fleck
    A quantitative and dynamic model for plant stem cell regulation.
    PLoS One 3, 2008, e3553 pdf
  • M. Reinhard, T.A. Gerds, D. Grabiak, P. Zimmermann, M. Roth, B. Guschlbauer, J. Timmer, M. Czosnyka, C. Weiller, A. Hetzel
    Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease.
    J. Neurology 255, 2008, 195-199 pdf
  • M. Reinhard, Z. Waldkircher, B. Guschlbaur, J. Timmer, C. Weiller, A. Hetzel
    Cerebellar autoregulation dynamics in humans.
    J. Cerebral Blood Flow Metabolism 28 pdf
  • S. Digiuni, S. Schellmann, F. Geier, B. Greese, M. Pesch. K. Wester, B. Dartan, V. Mach, B. P. Srinivas, J. Timmer, C. Fleck, M. Hülskamp
    A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves.
    Mol. Sys. Bio. 4, 2008, 217 pdf
    Supplementary Information
  • T. Maiwald, J. Timmer
    Dynamical modeling and multi-experiment fitting with PottersWheel.
    Bioinformatics 24, 2008, 2037-2043 pdf
    Supplementary Information
  • F. Amtage, K. Henschel, B. Schelter, J. Vesper, J. Timmer, C. Weiller, C.H. Lücking, B. Hellwig
    Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients.
    Neuroscience Lett. 442, 2008, 195-199 pdf
  • M. Joschko, J. Oehley, R. Gebbers, M. Wiemer, J. Timmer, C.A. Fox
    A spatial approach to soil-ecological experimentation at landscape scale.
    J. Plant Nutr. Soil Science 171, 2008, 339-343 pdf
  • M. Reinhard, C. Wihler, M. Roth, A. Harloff, W.-D. Niesen, J. Timmer, C. Weiller, A. Hetzel.
    Cerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis.
    Cerebrovascular Diseases 26, 2008, 147-155 pdf
  • Bartholome K, Timmer J.
    Regulatory principles and systems analysis of bacterial chemotaxis.
    AT Automatisierungstechnik 56, 2008, 241-249
  • D. Bouyer, F. Geier, F. Kragler, A. Schnittger, M. Pesch, K. Wester, R. Balkunde, J. Timmer, C. Fleck, M. Hülskamp.
    Two-dimensional patterning by a trapping/depletion mechanism: The role of TTG1 and GL3 in Arabidopsis trichome formation.
    PloS Biology 6, 2008, e141 pdf
  • J. Vera , J. Bachmann, A.C. Pfeifer, V. Becker, J.A. Hormiga, N.V. Torres Darias, J. Timmer, U. Klingmüller, O. Wolkenhauer.
    A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway.
    BMC Systems Biology 2, 2008, 38 pdf
    Supplementary Information
  • E. Balsa-Canto, M. Peifer, J.R. Banga, J. Timmer, C. Fleck.
    Hybrid optimization method with general switching strategy for parameter estimation.
    BMC Systems Biology 2, 2008, 26 pdf
  • A. Schad, K. Schindler, M. Winterhalder, B. Schelter, T. Maiwald, A. Brandt, J. Timmer, A. Schulze-Bonhage
    Application of a multivariate seizure detection and prediction method to non-invasive and intracranial long-term EEG recordings.
    Clinical Neurophysiology 119, 2008, 197-211 pdf
  • Allignol A, Beyersmann J, Schumacher M.
    mvna: An R Package for the Nelson–Aalen Estimator in Multistate Models.
    R News, 2008; 8: 48-50: http://CRAN.R-project.org/doc/Rnews
  • Wolkewitz M, Dettenkofer M, Bertz H, Schumacher M, Huebner J.
    Statistical epidemic modeling with hospital outbreak data.
    Stat Med, 2008; 27: 6522-6531: http://dx.doi.org/10.1002/sim.3419
  • Wolkewitz M, Vonberg RP, Grundmann H, Beyersmann J, Gastmeier P, Bärwolff S, Geffers C, Behnke M, Rüden H, Schumacher M.
    Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models.
    Crit Care, 2008; 12 (online): R44: http://dx.doi.org/10.1186/cc6852
  • Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
    Regression modelling in hospital epidemiology: a statistical note.
    Crit Care, 2008; 12: 427: http://dx.doi.org/10.1186/cc6991
  • Binder H, Sauerbrei W.
    Increasing the usefulness of additive spline models by knot removal.
    Computational Statistics & Data Analysis, 2008; 52: 5305-5318
  • Binder H, Schumacher M.
    Adapting prediction error estimates for biased complexity selection in high-dimensional bootstrap samples.
    Statistical Applications in Genetics and Molecular Biology, 2008; 7: Article 12
  • Binder H, Schumacher M.
    Allowing for mandatory covariates in boosting estimation of sparse high-dimensional survival models.
    BMC Bioinformatics, 2008; 9: 14
  • Binder H, Schumacher M.
    Comment on 'Network-constrained regularization and variable selection for analysis of genomic data'.
    Bioinformatics, 2008; 24: 2566-2568
  • Binder H, Tutz G: A comparison of methods for the fitting of generalized additive models. Statistics and Computing, 2008; 18: 87-99
  • Landgrebe M, Binder H, Koller M, Eberl Y, Kleinjung T, Eichhammer P, Graf E, Hajak G, Langguth B.
    Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius.
    BMC Psychiatry, 2008; 8: 1-9
  • Schoop R, Graf E, Schumacher M.
    Quantifying the predictive performance of prognostic models for censored survival data with time-dependent covariates.
    Biometrics, 2008; 64: 603-610 
  • Beyersmann J, Gastmeier P, Grundmann H, Bärwolff S, Geffers C, Behnke
    M, Rüden H, Schumacher M:
    Transmission-associated nosocomial infections: Prolongation of intensive care unit stay and risk factor analysis using multistate models
    Am J Infect Control, 2008; 36: 98-103
  • Beyersmann J, Schumacher M:
    Time-dependent covariates in the proportional subdistribution hazards model for competing risks.
    Biostatistics, 2008; 9: 765-776
  • Beyersmann J, Schumacher M:
    A note on nonparametric quantile inference for competing risks and more complex multistate models.
    Biometrika, 2008; 95: 1006-1008


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  • Maiwald T.,Kreutz C.,Pfeifer A.,Bohl S.,Klingmüller U.,Timmer J.
    Dynamic pathway modeling - Feasibility analysis and optimal experimental design.
    Annals New York Acad. Sci.1115, 2007, 212-220 pdf
  • Winterhalder M., Schelter B., Timmer J.
    Detecting coupling directions in multivariate oscillatory systems.
    Int. J. Bif. Chaos 17, 2007, 3735-3739 pdf
  • Schelter B., Winterhalder M., Kurths J., Timmer J.
    Phase synchronization and coherence analysis: sensitivity and specificity.
    Int. J. Bif. Chaos 17, 2007, 3551-3556 pdf
  • E. Anastasiou, S. Kenz, M. Gerstung, D. MacLean, J. Timmer, C. Fleck, M. Lenhard.
    Control of plant organ size by KLUH/CYP78A5-dependent intracellular signalling.
    Developmental Cell 13, 2007, 843-856 pdf
  • Kreutz C.,Bartholome Rodriguez M.M.,Maiwald T.,Seidl M.,Blum H.E., Mohr L., Timmer J.
    An error model for protein quantification.
    Bioinformatics 23, 2007, 2747-2753 pdf
    Supplementary Information
  • Hengl S., Kreutz C., Timmer J. Maiwald T.
    Data-dased identifiability analysis of nonlinear dynamical models.
    Bioinformatics 23, 2007, 2612-2618 pdf
    Supplementary Information
  • Rumberger B., Vonend O., Kreutz C., Wilpert J., Donauer J., Amann K., Rohrbach R., Timmer J., Walz G., Gerke P.
    cDNA mircoarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain.
    Kidney Blood Pressure Res. 30, 2007, 377-378 pdf
  • Bartholome K., Rius M., Letschert K., Keller D. Timmer J., Keppler D.
    Data-based mathematical modeling of vectorial transport across double-transfected polarized cells.
    Drug Metabolism and Disposition 35, 2007, 1476-1481 pdf
    Supplementary Information
  • Reinhard M., Wehrle-Wieland E., Roth M., Niesen W.D., Timmer, J. Weiller C., Hetzel A.
    Preserved dynamic cerebral autoregulation in the middle cerebral artery among persons with migraine.
    Exp. Brain Res. 180, 2007, 517-523 pdf
  • Schelter B., Peifer M., Winterhalder M., Timmer J.
    Testing for phase synchronization.
    Phys. Lett. A 366, 2007, 382-390 pdf
  • Peifer M., Timmer J.
    Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting.
    IET Systems Biology 1, 2007, 78-88 pdf
  • Lindenmeyer M.T., Kern C., Sparna T. Donauer J., Wilpert J., Schwager J., Porath D. Kreutz C., Timmer J., Merfort I.
    Microarray analysis reveals nfluence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.
    Life Sciences 80, 2007, 1608-1618 pdf
  • Geier F., Timmer J., Fleck C.
    Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge.
    BMC Systems Biology 1, 2007, 11 pdf
  • Schelter B., Winterhalder M., Feldwisch H., Wohlmuth J., Nawrath J., Brandt A., Schulze-Bonhage A., Timmer J.
    Seizure prediction: The impact of long prediction horizons.
    Epilepsy Research 73, 2007, 213-217 pdf
  • Smirnov D., Schelter B., Winterhalder M., Timmer J.
    Revealing direction of coupling between neuronal oscillators from time series: Phase dynamics modeling versus partial directed coherence.
    Chaos 17, 2007, 013111 pdf
  • Pfeifer D., Pantic M., Skatulla I., Rawluk J., Kreutz C., Martens U., Fisch P., Timmer J., Veelken H.
    Genome-wide analysis of DNA copy number changes in CLL using high-density SNP arrays.
    Blood 109, 2007, 1202-1210 pdf
  • Schumacher M, Wangler M, Wolkewitz M, Beyersmann J.
    Attributable mortality due to nosocomial infections - A simple and useful application of multistate models.
    /Method Inform Med/, 2007; 46: 595-600
  • Sauerbrei W, Royston P, Binder H.
    Selection of important variables and determination of functional form for continuous predictors in multivariable model building.
    Statistics in Medicine, 2007; 26: 5512-5528
  • Schumacher M, Binder H, Gerds TA.
    Assessment of survival prediction models based on microarray data.
    Bioinformatics, 2007; 23: 1768-1774
  • Tutz G, Binder H.
    Boosting ridge regression.
    Computational Statistics & Data Analysis, 2007; 51: 6044-6059
  • Beyersmann J:
    A random time interval approach for analysing the impact
    of a possible intermediate event on a terminal event.
    Biometrical J, 2007; 49: 742-749
  • Beyersmann J, Dettenkofer M, Bertz H, Schumacher M:
    A competing risks analysis of bloodstream infection after stem-cell transplantation using subdistribution hazards and cause-specific hazards.
    Stat Med, 2007; 26: 5360-5369
  • Meyer E, Beyersmann J, Bertz H, Wenzler-Röttele S, Babikir R,
    Schumacher M, Daschner FD, Rüden H, Dettenkofer M the ONKO-KISS Study
    Risk factor analysis of blood stream infection and pneumonia in neutropenic patients after peripheral blood stem-cell transplantation.
    Bone Marrow Transpl, 2007; 39: 173-178


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  • Sick S., Reinker S., Timmer J., Schlake T.
    WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.
  • Schelter B., Winterhalder M., Maiwald T., Brandt A., Schad A., Timmer J., Schulze-Bonhage A.
    Do false predictions of seizure depend on the state of vigilance? A report from two seizure prediction methods and proposed remedies.
    Epilepsia 47, 2006, 2058-2070 pdf
  • Klingmüller U., Bauer A., Bohl S., Nickel P., Breitkopf K., Dooley S., Zellmer S., Kern C., Merfort I, Sparna T., Donauer J., Walz G., Geyer M., Kreutz C., Hermes M., Götschel F., Hecht A., Walter D., Egger L., Neubert K., Borner C., Brulport M., Schormann W., Sauer C., Baumann F., Preiss R., MacNelly S., Godoy P., Wiercinska E., Ciuclan L., Edelmann J., Kleemann W.J., Zeilinger K., Heinrich M., Zanger U.M., Reuss M., Bader A., Gebhardt R., Maiwald T., Timmer J., von Weizsäcker F., Hengstler J.G.
    Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.
    IEE Proc. Systems Biology 153, 2006, 433-447 pdf
  • Winterhalder M., Schelter B., Hesse W., Schwab K., Leistritz L., Timmer J. and Witte H.
    Detection of directed information flow in multidimensional biosignals.
    Biomed. Tech. 51, 2006, 281-287 pdf
  • Warnke P.C., Kopitzki K., Timmer J., Ostertag C.B.
    Capillary physiology of human medulloblastoma - Impact on chemotherapy.
    Cancer 107, 2006, 2223-2227 pdf
  • Reinhard M., Wehrle-Wieland E., Grabiak D., Roth M., Guschlbauer B., Timmer J., Weiller C., Hetzel A.
    Oscillatory cerebral hemodynamics - the macro- vs. microvascular level.
    J. Neurol. Sci. 250, 2006, 103-109 pdf
  • Winterhalder M., Schelter B., Schulze-Bonhage A., Timmer J.
    Comment on: "Performance of a seizure warning algorithm based on the dynamics of intracranial EEG".
    Epilepsy Res. 72, 2006, 80-81 pdf
  • Winterhalder M., Schelter B., Maiwald T., Brandt A., Schad A., Schulze-Bonhage A., Timmer J.
    Spatio-temporal patient-individual assessment of synchronization changes for epileptic seizure prediction.
    Clin. Neurophys. 117, 2006, 2399-2413 pdf
  • Schieren G., Rumberger B., Klein M., Kreutz C., Wilpert J., Geyer M., Faller D., Timmer J., Quack I., Rump L.C., Walz G., Donauer J.
    TGene profiling of polycystic kidneys.
    Nephrol. Dial. Transplant. 21, 2006, 1816-1824
  • Reinker S., Altman R.M., Timmer J.
    Parameter estimation in stochastic biochemical reactions.
    IEE Trans. Syst. Biol. 153, 2006, 168-178 pdf
  • Winterhalder M., Schelter B., Kurths J., Schulze-Bonhage A., Timmer J.
    Sensitivity and specificity of coherence and phase synchronization analysis.
    Phys. Lett. A 356, 2006, 26-34 pdf
  • Petrov V., Peifer M., Timmer J.
    Bistability and self-oscillations in cell cycle control.
    Int. J. Bif. Chaos 16, 2006, 1057-1066 pdf
  • Schelter B., Winterhalder M., Eichler M., Peifer M., Hellwig B., Guschlbauer B., Lücking C.H., Dahlhaus R., Timmer J.
    Testing for directed influences among neural signals using partial directed coherence.
    Journal of Neuroscience Methods 152, 2006, 210-219 pdf
  • The Y.-K., Timmer J.
    Analysis of single ion channel data incorporating time interval omission and sampling.
    J. Roy. Soc. Interface 3, 2006, 87-97 pdf
  • Schelter, B., Winterhalder M., Maiwald T., Brandt A., Schad A., Schulze-Bonhage A., Timmer J.
    Testing statistical significance of multivariate time series methods for epileptic seizure prediction.
    Chaos 16, 2006, 013108 pdf
  • Joschko M., Fox,C., Lentzsch P., Kiesel J., Hierold W., Krück S., Timmer J.
    Spatial analysis of earthworm biodiversity at the regional scale.
    Agriculture, Ecosystems & Environment 112, 2006, 367-380 pdf
  • Schelter B., Winterhalder M., Hellwig B., Guschlbauer B., Lücking C.H., Timmer J.
    Direct or Indirect ? Graphical models for neural oscillators.
    J. Physiol. 99, 2006, 37-46 pdf
  • Eberlein E., Papapantoleon A., Kluge W.
    Symmetries in Lévy term structure models
    Applied Finance 9, 2006, 967-986
  • Tutz G, Binder H.
    Generalized additive modelling with implicit variable selection by likelihood based boosting.
    Biometrics, 2006; 62: 961-971
  • Beyersmann J, Gastmeier P, Grundmann H, Bärwolff S, Geffers C, Behnke
    M, Rüden H, Schumacher M:
    Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection.
    Infect Cont Hosp Ep, 2006; 27: 493-499
  • Rücker G, Schoop R, Beyersmann J, Schumacher M, Zuschneid I:
    Are KISS data representative of German intensive care units? - Statistical
    Method Inform Med, 2006; 45: 424-429
  • Wangler M, Beyersmann J, Schumacher M:
    changeLOS: An R-package for change in length of hospital stay based on the Aalen-Johansen estimator
    R News, 2006; 6: 31-35


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  • Kollmann M., Bartholome K., Lovdok L., Timmer J., Sourjik V.
    Design principles of a bacterial signalling network.
    Nature 438, 2005, 504-507 pdf
    Supplementary Information
  • Schilling M,. Maiwald T., Bohl S., Kollmann M., Kreutz C., Timmer J., Klingmüller U.
    Quantitative data generation for systems biology - the impact of randomisation, calibrators and normalisers.
    IEE Proc. Systems Biology 152, 2005, 193-200 pdf
  • Schilling M., Maiwald T., Bohl S., Kollmann M., Kreutz C., Timmer J., Klingmüller U.
    Computational processing and error reduction strategies for standardized quantitative data in biological networks.
    FEBS Journal 272, 2005, 6400-6411 pdf
    Supplementary Information
  • Winterhalder M., Schelter B., Hesse W., Schwab K., Leistritz L., Klan D., Bauer R., Timmer J., Witte H.
    Comparison of linear signal processing techniques to infer directed interactions in multivariate neural systems.
    Signal Processing 85, 2005, 2137-2160 pdf
  • Peifer M., Schelter B., Winterhalder M., Timmer J.
    Mixing properties of the Rossler system and consequences for coherence and synchronization analysis.
    Phys. Rev. E 72, 2005, 026213 pdf
  • Reinhard M., Roth M., Guschlbauer B., Harloff A., Timmer J., Czosnyka M., Hetzel A.
    Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations.
    Stroke 36, 2005, 1684-1689 pdf
  • Peifer M., Schelter B., Guschlbauer B., Hellwig B., Luecking C.H., Timmer J.
    On studentising and blocklength selection for the bootstrap on time series.
    Biometrical Journal 47,, 2005, 346-357 pdf
  • Petrov V., Peifer M., Timmer J.
    Structural stability analysis of a cell cycle control model.
    Comptes rendus de l'Acad. Bulg. Sci. 58, 2005, 19-24
  • The Y.-K., Fernandez J., Popa O., Lerche H., Timmer J.
    Estimating rate constants from single ion channel currents when the initial distribution is known.
    Eur. Biophys. J. 34 , 2005, 306-313 pdf
  • Goerttler P.S., Kreutz C., Donauer J., Faller D., Maiwald T., Klein M., März E., Rumberger B. Sparna T., Schmitt-Gräff A., Wilpert J., Timmer J., Walz G., Pahl H.
    Gene Expression Profiling in Polycythemia vera: Overexpression of transcription factor NF-E2.
    British Journal of Haematology 129, 2005, 138-150
  • Warnke P.C., Timmer J., Ostertag C.B., Kopitzki K.
    Capillary physiology and drug delivery in central nervous system lymphomas.
    Annals Neurology 57, 2005, 136-139 pdf
  • Tutz G, Binder, H.
    Localized classification.
    Statistics and Computing, 2005; 15: 155-166


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  • von Gruenberg H.H., Peifer M., Timmer J., Kollmann M.
    Variations in substitution rate in human and mouse genomes
    Phys. Rev. Lett. 93, 2004, 208102 pdf
  • Rossberg A., Bartholome K., Voss H.U., Timmer J.
    Phase synchronization from noisy univariate signals
    Phys. Rev. Lett. 93 , 2004, 154103 pdf
  • Petrov V., Timmer J.
    Bifurcation Analysis of a Cell Mitosis Control Model
    J. Theor. Appl. Mech. 34, 2004, 87-100.
  • Petrov V., Nikolova E., Timmer J.
    Dynamical Analysis of Cell Function Models.A Review
    J. Theor. Appl. Mech. 34, 2004, 55-78.
  • Petrov V., Peifer M., Timmer J.
    Constructing Dynamical Model of Cell Cycle Control
    Comptes Rendus de l'Acad. Bulg. Sci. 57, 2004, 15-22.
  • Maraun, D. , Rust, H. , and Timmer, J.
    Tempting long-memory - on the interpretation of DFA results
    Nonlinear Processes in Geophysics 11, 2004, 495-503 pdf
  • Steltner H., Vogel A., Sprung E., Timmer J., Guttmann J., Sorichter S.
    Incomplete forced expiration - estimating vital capacity by a mathematical method
    Respiration 71, 2004, 353-359
  • Raethjen J., Lauk M., Pawlas F., Koster B., Fietzek U., Friege L., Timmer J., Lucking C.H., Deuschl G.
    Tremor analysis in two normal cohorts
    Clin. Neurophys. 115, 2004, 2151-2156 pdf
  • Müller T.G., Faller D., Timmer J., Swameye I., Sandra O., Klingmüller U.
    Tests for cycling in a signalling pathway
    J. Roy. Stat. Soc. C: Applied Stat. 53, 2004, 557 - 568
  • Thiel M., Romano, M.C., Schwarz U., Kurths J., Timmer J.
    ;Surrogate based hypothesis test without surrogates
    Int. J. Bif. Chaos 14, 2004, 2107-2114 pdf
  • Maraun D., Horbelt W., Rust H., Timmer J., Happersberger H.P., Drepper F.
    Identificaton of rate constants and non-observable absorption spectra in nonlinear biochemical reaction dynamics
    Int. J. Bif. Chaos 14, 2004, 2081-2092 pdf
  • Müller T.G., Timmer J.
    Parameter identification techniques for partial differential equations
    Int. J. Bif. Chaos 14, 2004, 2053-2060, pdf
  • Timmer J., Müller T.G., Swameye I., Sandra O., Klingmüller U.
    Modelling the nonlinear dynamics of cellular signal transduction
    Int. J. Bif. Chaos 14, 2004, 2069-2079 pdf
  • Voss H.U., Timmer J., Kurths J.
    Nonlinear dynamical system identification from uncertain and incomplete measurements
    Int. J. Bif. Chaos 14, 2004, 1905-1933 pdf
  • Maiwald T., Winterhalder M., Aschenbrenner-Schiebe R., Voss H.U., Schulze-Bonhage A., Timmer J.
    Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristic
    Physica D 194, 2004, 357-368 pdf
  • Reinhard M., Roth M., Müller T, Guschlbauer B., Czosnyka M., Timmer J, Hetzel A.
    Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation
    Stroke 35, 2004, 1381-1387 pdf
  • Raethjen J., Lindemann M., Morsnowski A., Dümpelmann M., Wenzelburger R., Stolze H., Fietzek U., Pfister G., Elgar C.E., Timmer J., Deuschl G.
    Is the rhythm of physiological tremor involved in cortico-cortical interactions?
    Movement Disorders 19, 2004, 458-465
  • Faller D., Reinheckel T., Wenzler D., Hagemann S., Xiao K., Honerkamp J., Peters Ch., Dandekar T., Timmer J.
    An open source protein gel documentation system for proteome analyses
    J. Chem. Inf. Comp. Sci. 44, 2004, 168-169 pdf
  • Bertram C.D., Timmer J., Muller T.G., Maiwald T., Winterhalder M., Voss H.U.
    Aperiodic flow-induced oscillations of collapsible tubes: a critical reappraisal
    Medical Engineering & Physics 26, 2004, 201-214 pdf
  • Rossberg A.G., Bartholome K., Timmer J.
    Data driven optimal filtering for phase and frequency of noisy oscillations: application to vortex flowmetering.
    Phys. Rev. E 69, 2004, 016216 pdf
  • Rossberg A.G., Riegler P., Buhl F., Herwig J., Timmer J.
    Detection of improper installation from the sensor signal of vortex flowmeters.
    Flow Measurement and Instrumentation 15, 2004, 29-35
  • Tutz G, Binder H: Flexible modelling of discrete failure time including time-varying smooth effects. Statistics in Medicine, 2004; 23: 2445-2461


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  • Faller D., Klingmüller U., Timmer J.
    Simulation methods for optimal experimental design in systems biology
    Simulation: Trans. Soc. Modeling Computer Simulation 79, 2003, 717-725
  • Müller T., Lauk M., Reinhardt M., Hetzel A., Lücking C.H., Timmer J.
    Estimation of time-delays in biological systems
    Annals Biomed. Eng. 31, 2003, 1423-1439
  • Reinhard M., Müller T., Roth M., Guschlbauer B., Timmer J., Hetzel A.
    Bilateral severe carotid artery stenosis or occlusion - cerebral autoregulation dynamics and collateral flow patterns
    Acta Neurochirurgica 145, 2003, 1053-1060 pdf
  • Peifer M., Timmer J., Voss H.U.
    Non-parametric identification of non-linear oscillating systems
    J. Sound Vib. 267, 2003, 1157-1167
  • Aschenbrenner-Schiebe R., Maiwald T., Winterhalder M., Voss H.U., Timmer J., Schulze-Bonhage A.
    How well can epileptic seizures be predicted? An evaluation of a nonlinear method
    Brain 216, 2003, 2616-2626 pdf
  • Donauer J., Rumberger B.G., Klein M., Faller D., Wilpert J., Sparna T., Schieren G., Rohrbach R., Dern P., Timmer J., Pisarski P., Kirste G., Walz G.
    Expression profiling on chronically rejected transplant kidneys.
    Transplantation 76, 2003, 539-547. pdf
  • Reinhard, M., Roth, M., Müller, T., Czosnyka, M., Timmer, J., Hetzel, A.
    Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index.
    Stroke 34, 2003, 2138-2244 pdf
  • Kappler B., Tuchbreiter A., Faller D., Liebetraut P., Horbelt W., Timmer J., Honerkamp J., Mülhaupt R.
    Real-time monitoring of ethene/1-hexene copolymerizations: Determination of catalyst activity, copolymer composition and copolymerization parameters
    Polymer 44, 2003, 6179-6186 pdf
  • Faller D., Voss H.U., Timmer J., Hobohm U.
    Normalization of DNA-mircoarray data by nonlinear correlation maximization
    J. Comp. Biol. 10, 2003, 751-761 pdf
  • Reinhard M., Roth M., Müller T., Guschlbauer B., Timmer J., Hetzel A.
    Dynamic cerebral autoregulation and collateral flow patterns in patients with severe carotid stenosis or occlusion.
    Ultrasound Med. Biol. 29, 2003, 1105-1113 pdf
  • Hellwig B., Schelter B., Guschlbauer B., Timmer J., Lücking C.H.
    Dynamic synchronisation of central oscillators in essential tremor
    Clinical Neurophysiology 114, 2003, 1462-1467 pdf
  • Voss H.U., Rust H., Horbelt W., Timmer J.
    A combined approach for the identification of continuous nonlinear systems
    Int. J. Adaptive Control 17, 2003, 335-352
  • Winterhalder M., Maiwald T., Aschenbrenner-Schiebe R., Voss H.U., Timmer J., Schulze-Bonhage A.
    The seizure prediction characteristic: A general framework to assess and compare seizure prediction methods
    Epilepsy and Behavior 4, 2003, 318 - 325 pdf
  • Horbelt W., Timmer J.
    Asymptotic scaling laws for precision of parameter estimates in dynamical systems
    Phys. Lett. A 310, 2003, 269-280 PostScript
  • Müller T., Reinhard M., Oehm E., Hetzel A., Timmer J.
    Detection of very low frequency oscillations of cerebral hemodynamics is influenced by data detrending
    Med. & Biol. Eng. & Comp. 41, 2003, 1028-1033 pdf
  • Swameye I., Müller T.G., Timmer J., Sandra O., Klingmüller U.
    ;Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based modeling
    Proc. Natl. Acad. Sci. 100, 2003, 1028-1033 pdf
  • Reinhard M., Müller T., Guschlbauer B., Timmer J., Hetzel A.
    Transfer function analysis for clinical evaluation of dynamic of cerebral autoregulation - a comparison between spontaneous and respiratory-induced oscillations
    Physiolog. Measurement 24, 2003, 27-45.
  • Horbelt W., Timmer J., Bünner M., Meucci R., Ciofini M.
    Dynamical modelling of measured time series from a Q-switched CO_2 laser
    Chaos, Solitons & Fractals 17, 2003, 397-404


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  • Kopitzki K., Saparin P., Kurths J., Warnke P., Timmer J.
    Comment on "Kullback-Leibler and renormalized entropies: Application to electroencephalograms of epileptic patients"
    Phys. Rev. E 66, 2002, 043902, PostScript
  • Horbelt W., Voss H.U., Timmer J.
    Parameter estimation in nonlinear delayed feedback systems from noisy data
    Phys. Lett. A 299, 2002, 513-521, pdf
  • Müller T.G., Timmer J.
    Fitting parameters in partial differential equations from partially observed noisy data
    Physica D 171, 2002, 1-7, PostScript
  • Köster B., Deuschl G., Lauk M., Timmer J., Guschlbauer B., Lücking C.H.
    Essential tremor and cerebellar dysfunction: Abnormal ballistic movements
    J. Neurology, Neurosurgery, Psychiatry 73, 2002, 400-405, pdf
  • Altenburger R., Heitz C., Timmer J.
    Analysis of phase resolved partial discharge patterns of voids based on a stochastic process approach.
    J. Physics D: Applied Physics 35, 2002, 1149-1163, gzipped PostScript
  • Steltner H., Staats R., Timmer J., Vogel M., Guttmann J., Matthys H., Virchow J.C.
    Diagnosis of sleep apnea based on automatic analysis of nasal pressure and forced oscillation impedance.
    Am. J. Resp. Crit. Care Med. 165, 2002, 940-944
  • The Y.-K., Wagner M., Timmer J.
    Method Independent Effects in Testing for Detailed Balance in Ion Channels Gating.
    Biophys. J. 82, 2002, 2275-2276
  • Müller T., Noykova N., Gyllenberg M., Timmer J.
    Parameter identification in a dynamical model of anaerobic waste water treatment processes.
    Math. Biosciences 177-178, 2002, 147-160
  • Noykova N., Müller T., Gyllenberg M., Timmer J.
    Quantitative analysis of anaerobic wastewater treatment processes: identifiability and parameter estimation.
    Biotech. & Bioeng. 78, 2002, 89-103
  • Walkenhorst O., Luther J., Reinhart Ch., Timmer J.
    Dynamic annual indoor illuminance simulations based on one-hour and one-minute means of irradiance data.
    Solar Energy 72, 2002, 385-395
  • Kristeva-Feige R., Fritsch Ch., Timmer J., Lücking C.H.
    Influence of distraction of attention and precision level of exerted force on beta range EEG-EMG synchronization during maintainted motor contraction task.
    Electroenceph. clin. Neurophys. 113, 2002, 124-131
  • Raethjen J., Lindemann M., Dmpelmann M., Wenzelburger R., Stolze H., Pfister G., Elgar C., Timmer J., Deuschl G.
    Corticomuscular coherence in the 6-15 Hz band. Does the central component of physiological tremor originate from the cortex?
    Exp. Brain. Res. 142, 2002, 32-40


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  • Horbelt W., Timmer J., Bünner M.J., Meucci R., Ciofini M.
    Identifying physical preperties of a C02 laser by dynamical modeling of measured time series.
    Phys. Rev. E 64, 2001, 016222
  • Lauk M., Timmer J., B. Guschlbauer, Hellwig B., Lücking C.H.
    Variability of frequency and phase between antagonistic muscle pairs in pathological human tremors.
    Muscle & Nerve 24, 2001, 1365-1370
  • Lindemann M., Raethjen J., Timmer J., Deuschl G., Pfister G.
    Delay estimation for cortico-peripheral relations.
    J. Neuroscience Methods 111, 2001, 127-139
  • Michalek S., Wagner M., Vach W., Timmer J.
    Finite size properties of maximum likelihood estimators and likelihood ratio tests in Hidden Markov Models.
    Biometrical J. 43, 2001, 863-879
  • Reinhardt M., Hetzel A., Lauk M. and Lücking C.H.
    Evaluation of impaired dynamic cerebral autoregulation by the Mueller manoeuvre.
    Clinical Physiology 21, 2001, 229-237
  • Reinhardt M., Hetzel A., Lauk M. and Lücking C.H.
    Dynamic cerebral autoregulation testing as a diagnostic tool in patients with carotid artery stenosis
    Neurological Research 23, 2001, 55-63
  • Steltner H., Vogel M., Sorichter S., Matthys H., Guttmann J., Timmer J.
    Analysis of forced expired volume signals using multiexponential functions
    Medical & Biological Engineering & Computing 39, 2001, 190-194
  • Hellwig, B., Häussler, S., Schelter, B., Lauk, M., Köster, B., Guschlbauer, B., Timmer, J., Lücking, C.H.
    Electroencephalography reveals tremor-correlated cortical activity in patients with essential tremor
    The Lancet 357, 2001, 519-523
  • Wagner M., Timmer J.
    Model selection in non-tested Markov models for ion-channel gating
    J. Theo. Biol. 208, 2001, 439-450, gzipped PostScript


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  • J. Timmer, M. Lauk, B. Köster, B. Hellwig, S. Häußler, B. Guschlbauer, V. Radt, M. Eichler, G. Deuschl, C.H. Lücking
    Cross-spectral analysis of tremor time series
    Int J Bif Chaos 10, 2000, 2595-2610, gzipped PostScript
  • Wagner M., Timmer J.
    The effects of non-identifiability on testing for detailed balance in aggregated Markov models of ion-channel gating
    Biophys. J. 79,2000, 2918-2924, PostScript
  • Timmer J., Rust H., Horbelt W., Voss H.U.
    Parametric, nonparametric and parametric modeling of a chaotic circuit time series
    Phys. Lett.A 274, 2000, 123-134, gzipped PostScript
  • Reisch S., Daniuk J., Steltner H., Rühle, K.-H., Timmer J., Guttmann J.
    Detection of sleep apnea with the forced oscillation technique compared to the three polysomnographic signals.
    Respiration 67, 2000 518-525
  • Reisch S., Timmer J., Steltner H., Rühle K.-H., Ficker J.H., Guttmann J.
    Detection of obstructive sleep apnea by analysis of phase angle using the forced oscillation signal
    Respiration Physiology123, 2000, 87-99
  • Timmer J.
    What can be inferred from surrogate data testing?
    Phys. Rev. Lett. 85, 2000, 2647, PostScript
  • S. Michalek, M. Wagner, and J. Timmer
    Maximum approximate likelihood estimator for MA-filtered hidden Markov models.
    IEEE Transactions on Signal Processing 48, 2000, 1537-1547
  • Timmer J.
    Parameter estimation in nonlinear stochastic differential equations
    Chaos, Solitons & Fractals 11, 2000 , 2571-2578, PostScript
  • Timmer J., Horbelt W., Bünner M., Ciofini M., Meucci R.
    Estimating Parameters in Differential Equations with Application to Laser Data
    in D.S. Broomhead, E.A. Luchinskaya, P.V.E. McClintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the Lakes, American Institute of Physics, Woodbury, NY, USA, 2000, 617-623
  • Timmer J., Häußler S., Lauk M., Lücking C.H.
    Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators?
    Chaos 10 , 2000, 278-288, gzipped PostScript
  • Timmer J., Häußler S., Lauk M., Lücking C.H.
    Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators?
    in D.S. Broomhead, E.A. Luchinskaya, P.V.E. McClintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the LakesAmerican Institute of Physics, Woodbury, NY, USA, 2000, 197-202, gzipped PostScript
  • B. Hellwig, S. Häußler, M. Lauk, B. Köster, B. Guschlbauer, R. Kristeva-Feige, J. Timmer, and C.H. Lücking
    Electroencephalography reveals tremor-correlated cortical activity in patients with Parkinson's disease.
    Electroencephalography and Clinical Neurophysiology, 2000, 806-809
  • Müller T., Ball T., Kristeva-Feige R., Mergner T., Timmer J.
    Selecting relevant electrode positions for classification tasks based on the electro-encephalogram
    Medical & Biological Engineering & Computing 38 , 2000, 62-67
  • Timmer J., Schwarz U., Voss H.U., Wardinski I., Belloni T., Hasinger G., van der Klis M., Kurths J.
    Linear and nonlinear time series analysis of the black hole candidate Cygnus X-1
    Phys. Rev. E 61 , 2000, 1342-1352, gzipped PostScript


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  • Lauk M., Chow, C.C., Lipsitz, L.A., Mitchell, S.L.,and Collins, J.J.
    Assessing muscle stiffness from quiet stance in Parkinson's disease
    Muscle & Nerve 22, 1999, 635-639
  • H. Voss, P. Kolodner, M. Abel, and J. Kurths
    Amplitude equations from spatiotemporal binary-fluid convection data
    Phys. Rev. Lett. 83, 3422-3425 (1999).
  • H. Voss, A. Schwache, J. Kurths, and F. Mitschke
    Equations of motion from chaotic data: A driven optical fiber ring resonator
    Physics Letters A 256, 47-54 (1999).
  • H. Voss and J. Kurths
    Reconstruction of nonlinear time delay models fromoptical data
    Chaos, Solitons and Fractals 10, 805-809 (1999).
  • Michalek S., Timmer J.
    Estimating rate constants in Hidden Markov Models by the EM algorithm
    IEEE Trans. Signal Proc. 47, 1999, 226-228
  • König M., Paunzen E., Timmer J.
    On the irregular behaviour of the variable star R Scuti.
    Monthly Notices Royal Astronomical Society 303 , 1999, 297-300
  • Timmer J., Lauk M., Vach W., Lücking C.H.
    A test for a difference between spectral peak frequencies
    Comp Stat Data Analysis 30 , 1999, 45-55, gzipped PostScript
  • Köster B., Lauk M., Timmer J., Poersch M., Guschlbauer B., Glocker F.X., Deuschl G., Lücking C.H.
    Involvement of cranial muscles in orthostatic tremor
    Ann. Neur. 45 , 1999, 384-388
  • Lücking C.-H., Köster B., Guschlbauer B., Lauk M., Timmer J.
    Parkinsonian and essential tremor: Different entities or different manifestations of the same disorder
    Advances in Neurology 80, 1999, 335-339
  • Lauk M., Timmer J., Lücking C.H., Honerkamp J., Deuschl G.
    A software for recording and analysis of human tremor
    Computer Methods and Programs in Biomedicine 60 , 1999, 65-77, gzipped PostScript
  • Reisch S., Steltner H., Timmer J., Renotte C., Guttmann J.
    Early detection of upper airway obstructions by analysis of acoustical respiratory input impedance
    Biological Cybernetics 81, 1999, 25-37
  • Glocker F.X., Lauk M., Föll D., Köster B., Guschlbauer B., Timmer J., Deuschl G., Lücking C.H.
    Classical conditioning of the electrically elicited blink reflex in humans: A new method of data analysis
    J. Neuroscience Methods 89 , 1999, 133-140
  • S. Michalek, H. Lerche, M. Wagner, N. Mitrovic, M. Schiebe, F. Lehmann-Horn and J. Timmer
    On identification of sodium channel gating schemes using moving-average filtered hidden Markov models
    Europ. Biophys. J. 28 , 1999, 605-609, gzipped PostScript
  • M. Wagner, S. Michalek, and J. Timmer
    Estimating rate constants in aggregated Markov models of ion channel gating with loops and with with nearly equal dwell times
    Proc. Roy. Soc. B 266 , 1999, 1919-1926, gzipped PostScript
  • Lauk M., Köster B., Timmer J., Guschlbauer B., Deuschl G. and Lücking C.H.
    Side-to-side correlation of muscle activity in physiological and pathological human tremors
    Electroencephalography and Clinical Neurophysiology 110 , 1999, 1774-1783
  • Pavlik A.E., Inglis J.T., Lauk M., Oddsson L., and Collins J.J.
    The Effects of Stochastic Galvanic Vestibular Stimulation on Human Postural Sway
    Exp. Brain Res. 124, 1999, 273-80
  • Chow C.C., Lauk M., and Collins J.J.
    The Dynamics of Quasistatic Posture Control
    Human Movement Science 18, 1999, 725-740


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  • Augustin, N.H., Mugglestone, M.A. and Buckland, S.T.
    The role of simulation in modelling spatially correlated data
    Environmetrics, 9, 175-196, 1998
  • Augustin, N.H., Borchers, D.L., Clarke, E.D., Buckland, S.T. and Walsh, M.
    Spatio-temporal modelling for the annual egg production method of stock assessment using generalised additive models
    Canadian Journal of Fisheries and Aquatic Sciences. 55, 2608-2621, 1998
  • H. Voss and J. Kurths
    Test for nonlinear dynamical behavior in symbol sequences
    Physical Review E 58, 1155-1158 (1998).
  • H. Voss, M. J. Bünner, and M. Abel
    Identification of continuous, spatiotemporal systems
    Physical Review E 57, 2820-2823 (1998).
  • H. Voss
    Nichtlineare statistische Methoden zur Datenanalyse
    Dissertation im Fachgebiet Physik-Nichtlineare Dynamik
    Eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät der Universität Potsdam, Mai 1998.
  • Köster B., Lauk M., Timmer J., Winter T., Guschlbauer B. Glocker F.X., Danek A., Deuschl G., Lücking C.H.
    Central mechanisms in human enhanced physiological tremor
    Neuroscience Letters 241, 1998, 135-138, gzipped PostScript
  • Gezeck S., Timmer J.
    Detecting multimodality in Saccadic reaction time distributions in gap and overlap tasks
    Biolog. Cybern. 78 , 1998, 293-305
  • Timmer J., Lauk M., Pfleger W., Deuschl G.
    Cross-spectral analysis of physiological tremor and muscle activity. I: Theory and application to unsynchronized EMG
    Biolog. Cybern. 78 , 1998, 349-357, gzipped PostScript
  • Timmer J., Lauk M., Pfleger W., Deuschl G.
    Cross-spectral analysis of physiological tremor and muscle activity. II: Application to synchronized EMG
    Biolog. Cybern. 78 , 1998, 359-368, gzipped PostScript
  • Timmer J., Müller T., Melzer W.
    Numerical methods for the determination of calcium release from calcium transients in muscle data
    Biophys. J. 74 , 1998, 1694-1706, gzipped PostScript
  • Horbelt W., Timmer J., Melzer W.
    Estimating parameters in nonlinear differential equations with application to physiological data
    in: G. Osipenko, ed., Differential equations and applications, 1998, 23-33
  • Horbelt W., Timmer J., Bünner M., Honerkamp J.
    Estimating parameters in nonlinear differential equations with application to Q-switched lasers
    Technische Anwendungen von Erkenntnissen der Nichtlinearen Dynamik, 1998, 311-314
  • Timmer J.
    The power of surrogate data testing with respect to non-stationarity
    PRE 58 , 1998, 5153-5156, gzipped PostScript
  • Kopitzki K., Warnke P., Timmer J.
    Quantitative analysis by renormalized entropy of invasive electroencephalograph recordings in focal epilepsy
    PRE 58 , 1998, 4859-4864, zipped PostScripts
  • Timmer J.
    Modeling noisy time series: Physiological tremor
    Int. J. Bif. Chaos 8 , 1998, 1505-1516, gzipped PostScript
  • Reisch S., Schneider M., Timmer J., Geiger K., Guttmann J.
    Evaluation of forced oscillation technique for early detection of airway obstruction in sleep apnea: a model study
    Tech. Health Care 6 , 1998, 245-257
  • Lauk M., Chow C.C., Pavlik A.E. and Collins J.J.
    Human balance out of equilibrium: Nonequilibrium statistical mechanics in posture control
    Phys. Rev. Lett. 80, 1998, 413-416


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  • Buckland, S. T., Burnham, K.P. and Augustin, N.H.
    Model selection: An integral part of inference
    Biometrics, 53, 603-618, 1997.
  • H. Voss and J. Kurths
    Reconstruction of nonlinear time delay models from data by the use of optimal transformations
    Physics Letters A 234, 336-344 (1997).
  • J. Kurths, U. Feudel, W. Jansen, U. Schwarz, H. Voss
    Solar Variability: Simple Models and Proxy Data
    G Cini Castagnoli (Ed.), Proceedings of the International School of Physics ``Enrico Fermi'', Varenna (1997).
  • Klein S., Timmer J., Honerkamp J.
    Analysis of multichannel patch clamp recordings by Hidden Markov Models
    Biometrics 53, 1997, 870-884
  • Timmer J., Klein S.
    Testing the Markov condition in ion channel recordings
    Phys. Rev. E 55, 1997, 3306-3310
  • König M., Friedrich S., Staubert R., Timmer J.
    The Seyfert Galaxy NGC 6814 -- a highly variable X-ray source
    Astronomy and Astrophysics 322, 1997, 747-750
  • Gezeck S., Fischer B., Timmer J.
    Saccadic reaction times: a statistical analysis of multimodal distributions
    Vision Research 37, 1997, 2119-2131
  • König M., Timmer J.
    Analyzing X-ray variability by Linear State Space Models
    Astronomy and Astrophysics, SS 124, 1997, 589-596, gzipped PostScript
  • Timmer J., Lauk M., Lücking C.H.
    Confidence regions for spectral peak frequencies
    Biometrical J. 39, 1997, 849-861, gzipped PostScript
  • Timmer J., Weigend A.
    Modeling volatility using state space models
    Int. J. Neur. Syst. 8 , 1997, 385-398, gzipped PostScript
  • Heitz C., Timmer J.
    Using Optimized Time-Frequency Representations for Acoustic Quality Control of Motors
    Acta Acoustica 83, 1997, 1053-1064, PostScript
  • S. Lauer, J. Timmer, D. van Calker, D. Maier, J. Honerkamp
    Optimal weighed Bayesian design applied to dose-response-curve analysis
    Communications in Statistics - Theory and Methods 26, 1997, 2879-2903


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  • Augustin, N.H., Mugglestone, M.A. and Buckland, S.T.
    An autologistic model for the spatial distribution of wildlife.
    Journal of Applied Ecology, 33, 339-347, 1996.
  • Augustin, N.H., Borchers, D.L., Mugglestone, M.A. and Buckland, S.T.
    Regression methods with spatially referenced data.
    Aspects of Applied Biology, 46, 67-74, 1996.
  • H. Voss, J. Kurths, and U. Schwarz
    Reconstruction of grand minima of solar activity from radiocarbon data
    Journal of Geophysical Research 101, 15,637-15,643 (1996).
  • G. Deuschl, P. Krack, M. Lauk, J. Timmer
    Clinical neurophysiology of tremor with relation to clinical diagnosis and pathophysiology
    Journal of Clinical Neurophysiology, 13, 1996, 110
  • Gebicke-Härter P., Christoffel F., Timmer, J., Norhoff H., Berger M., van Calker D.
    Both Adenosine A1- and A2-receptors are required to stimulate microglial proliferation
    Neurochemistry International, 29, 1996, 37-42
  • Weyerbrock A., Timmer J., Hohagen F., Berger M., Bauer J.
    Effects of light and chronotherapie on human circadian rhythm in delayed sleep phase syndrom (DSPS): cytokines, cortisol, growth hormone and the sleep-wake cycle
    Biological Psychiatry 40, 1996, 794-797
  • J. Timmer, M. Lauk, G. Deuschl
    Quantitative analysis of tremor time series
    Electroencephalography and Clinical Neurophysiology 101, 1996, 461-468
  • M. Bohus, U. Förstner, C. Kiefer, P. Gebicke-Härter, J. Timmer, G. Spraul, H. Wark, H. Hecht, M. Berger, D. van Calker
    Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute Major Depressive episodes
    Psychiatry Research 65, 1996, 45-61


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  • Heitz C.
    Optimum time-frequency representations for the classification and detection of signals
    Appl. Sig. Proc.3 1995, 124-143
  • Ernst Eberlein, Ulrich Keller
    Hyperbolic Distributions in Finance
    Bernouilli 1/1995, S. 281-299 PostScript
  • Krieger S., Timmer J., Lis S., Olbrich H.M.
    Some considerations on the Interpretation of Event-Related-Potentials
    Journal of Neural Transmission 99, 1995, 103-129
  • Deuschl G., Lauk M., Timmer J.<;/div>
    Tremor Classification and Tremor Time Series Analysis
    Chaos 5, 1995, 48-52
  • Timmer J., König, M.
    On generating power law noise
    Astronomy and Astrophysics, 300, 1995, 707


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  • Bauer J., Hohagen F., Elbert T., Timmer J., Ganter U., Krieger S., Lis S., Postler E., Voderholzer U., Berger M.
    Interleukin-6 Serum Levels in Healthy Persons correspond to the Sleep-Wake-Cycle
    Clinical Investigator 72, 1994, 312
  • Jedynak A., Bach M., Timmer J.
    Failure of Dimension Analysis in a simple Five-Dimensional System
    Phys. Rev. E 50, 1994, 1770-1780


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  • Timmer, J., Gantert, C., Deuschl, G., Honerkamp, J.
    Characteristics of Hand Tremor Time Series
    Biol. Cybern. 70, 1993, 75-80
  • Hohagen F., Timmer J., Weyerbrock A., Fritsch-Monero R., Ganter U., Krieger S., Berger M., Bauer J.
    Cytokine Production during Sleep and Wakefulness and its Relationship to Cortisol in Healthy Humans
    Neuropsychobiology 28, 1993, 9-16


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  • Gantert C., Honerkamp J., Timmer J.
    Analysing the dynamics of hand tremor time series
    Biol. Cybern. 66, 1992, 479-484





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