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Prof. Peter Pfaffelhuber und Peter Czuppon

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Noise in autoregulated gene expression

Was
  • FDM-Seminar
Wann 23.12.2016
von 12:00 bis 12:00
Wo Eckerstraße 1, Raum 404, 4. OG
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Gene expression is the foundation of molecular biology. Genes can be active or deactive; active genes are transcribed into RNA; RNA is translated into functional protein. Since the chemical reaction network for these processes is linear, it can be solved explicitly. In contrast, we are dealing with genes regulating their own expression. A negative feedback arises when protein binds to the gene and (de-)activates it, leading to a positive (negative) feedback. Using the assumption of fast activation and deactivation of genes, we are interested in gene expression noise under feedback. Using an approach of Kang, Kurtz and Popovic, we can quantify the reduction of noise under negative feedback and the increase in noise under positive feedback.

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