The Tremor Project

The new tremor project homepage (currently under construction).

Tremor is characterised by involuntary movements of parts of the body, especially of the upper limbs. Different forms of tremor, like tremor in Parkinson's disease or essential tremor are assumed to have different pathophysiological backgrounds.

Aim of the project

For a better understanding of the mechanisms underlying tremor and its generation, multivariate analysis techniques are used to infer the interaction structure between the trembling muscles and regions of the brain, which are supposed to be involved in the generation of tremor. Improving the knowledge of the pathophysiology of the different forms of tremor could enhance the success of therapies like stereotactic neurosurgery or medication.

The Team

Prof. Dr. Jens Timmer (Freiburg Center for Data Analysis and Modeling, Freiburg, Germany)

Dr. Björn Schelter (Freiburg Center for Data Analysis and Modeling, Freiburg, Germany)

Linda Sommerlade (Freiburg Center for Data Analysis and Modeling, Freiburg, Germany)

Olga Lapp (Freiburg Center for Data Analysis and Modeling, Freiburg, Germany)

Dr. Florian Amtage (Department of Neurology, University Medical Center Freiburg, Germany)

PD Dr. Bernhard Hellwig (Department of Neurology, University Medical Center Freiburg, Germany)

Prof. Dr. Carl Hermann Lücking (Department of Neurology, University Medical Center Freiburg, Germany)

Prof. Dr. Cornelius Weiller (Department of Neurology, University Medical Center Freiburg, Germany)

For contact concerning this project, please send an email to Kathrin Henschel.

Publications

• Timmer, J., Gantert, C., Deuschl, G., Honerkamp, J.:
  Characteristics of Hand Tremor Time Series, Biol. Cybern. 70, 1993, 75-80
  

• Deuschl G., Lauk M., Timmer J.:
  Tremor Classification and Tremor Time Series Analysis, Chaos 5, 1995, 48-52
  

• Timmer J., Lauk M., Deuschl G.:
  Quantitative Analysis of Tremor Time Series, Electroencephalography and Clinical Neurophysiology 101, 1996, 461-468
  

• Deuschl G., Krack P., Lauk M., Timmer J.:
  Clinical neurophysiology of tremor, Journal of Clinical Neurophysiology 13, 1996, 110-121
  

• Timmer J., Lauk M., Pfleger W., Deuschl G.:
  Cross-spectral analysis of physiological tremor and muscle activity. I.: Theory and application to unsynchronized EMG Biological Cybernetics 78, 1998, 349-357
  

• Timmer J., Lauk M., Pfleger W., Deuschl G.:
  Cross-spectral analysis of physiological tremor and muscle activity. II.: Application to synchronized EMG Biological Cybernetics 78, 1998, 359-368
  

• Timmer J., Lauk M. and Lücking C.H.:
  Confidence regions for spectral peak frequencies , Biometrical Journal 39, 1997, 849-861
  

• Lauk M., Timmer J., Lücking C.H., Honerkamp J., and Deuschl G.:
  A software for recording and analysis of human tremor , Comput. Methods Programs Biomed. 60, 1999, 65-77
  

• Köster B., Lauk M., Timmer J., Winter T., Guschlbauer B., Glocker F.X., Danek A., Deuschl G. and Lücking C.H.:
  Central mechanisms in enhanced physiological tremor Neurosc. Lett. 241, 1998, 135-138
  

• Timmer J., Lauk M., Vach W. and Lücking C.H.:
  A test for a difference between spectral peak frequencies. Comp. Stat. Data Analysis, 30, 1999, 45-55
  

• Timmer J.:
  Modeling noisy time series: Physiological tremor Int. J. Bif. Chaos 8, 1998
  

• Lauk M., Köster B., Timmer J., Guschlbauer B., Deuschl G. and Lücking C.H.:
  Side-to-side correlation of muscle activity in physiological and pathological human tremors, Clin. Neurophysiol. 110, 1999, 1774-1783
  

• Köster B., Lauk M., Timmer J., Poersch M., Guschlbauer B., Deuschl G. and Lücking C.H.:
  Involvement of cranial muscles and high intermuscular coherence in orthostatic tremor Ann. Neurol. 45, 1999, 384-388
  

• Hellwig B., Häußler S., Lauk M., Guschlbauer B., Köster B., Kristeva-Feige R., Timmer J., and Lücking C.H.:
  Tremor-correlated cortical activity detected by electroencephalography. 111, 2000, 806-809
  

• Timmer J., Häußler S., Lauk M., and Lücking C.H.:
  Pathological tremors: Deterministic Chaos or non-linear stochastic oscillators? CHAOS 10, 2000, 278-288
  

• Lücking C.H., Köster B., Guschlbauer B., Lauk M., and Timmer J.:
  Parkinsonian and essential tremor: Different entities or different manifestations of the same disorder? Adv Neurol. 80, 1999, 335-339
  

• Timmer J., Lauk M., Köster B., Hellwig B., Häußler S., Guschlbauer B., Radt V., Eichler M., Deuschl G. and Lücking C.H.:
  Cross-spectral analysis of tremor time series Int. J. Bif. Chaos, 10 , 2000, 2595-2610
  

• Lauk M., Timmer J., Guschlbauer B., Hellwig B., Lücking C.H.:
  Variability of frequency and phase between antagonistic muscle pairs in pathological human tremors, Muscle & Nerve 24 , 2001, 1365-1370
  

• Hellwig B., Häußler S., Schelter B., Lauk M., Köster B., Guschlbauer B., Timmer J., Lücking C.H.:
  Tremor-correlated cortical activity in essential tremor The Lancet 357 , 2001, 519-523,
  

• M. Lauk, J. Timmer, C.H. Lücking, G. Deuschl, J. Honerkamp.:
  An application for the analysis of human tremor time-series in: Mathematik - Schlüsseltechnologie für die Zukunft, Heidelberg, Springer, 2001
  

• Lindemann M., Raethjen J., Timmer J., Deuschl G., Pfister G.:
  Delay estimation for cortico-peripheral relations J. Neuroscience Methods, 111, 2001, 127-139
  

• Raethjen J., Lauk M., Pawlas F., Köster B., Lücking C.H., Timmer J., Deuschl G.:
  Normative study of physiological hand tremor
  

• Lauk M., Timmer J., Inglis J.T., Reinhardt M., Lücking C.H., Collins J.J.:
  Interpretation of phase spectra and estimation of time-delays in biological systems
  

• Raethjen J., Lindemann M., Dümpelmann M., Wenzelburger R., Stolze H., Pfister G., Elgar C., Timmer J., Deuschl G.:
  Corticomuscular coherence in the 6-15 Hz band. Does the central component of physiological tremor originate from the cortex? Exp. Brain. Res. 142, 2002, 32-40
  

• Kristeva-Feige R., Fritsch Ch., Timmer J., Lücking C.H.:
  Influence of distraction of attention and precision level of exerted force on beta range EEG-EMG synchronization during maintainted motor contraction task, Electroenceph. clin. Neurophys. 113 , 2002, 124-131
  

• Köster B., Deuschl G., Lauk M., Timmer J., Guschlbauer B., Lücking C.H.:
  Essential tremor and cerebellar dysfunction: Abnormal ballistic movements
  J. Neurology, Neurosurgery, Psychiatry 73 , 2002, 400-405
  

• Hellwig B., Schelter B., Guschlbauer B., Timmer J., Lücking C.H.:
  Dynamic synchronisation of central oscillators in essential tremor, Clin. Neurophys 114, 2003, 1462-1467
  

• Müller T., Lauk M., Reinhardt M., Hetzel A., Lücking C.H., Timmer J.:
  Estimation of time-delays in biological systems
  Annals Biomed. Eng. 31, 2003, 1423-1439
  

• Raethjen J., Lauk M., Pawlas F., Koster B., Fietzek U., Friege L., Timmer J., Lucking C.H., Deuschl G.:
  Tremor analysis in two normal cohorts , Clin. Neurophys. 115, 2004, 2151-2156
  

• Raethjen J., Lindemann M., Morsnowski A., Dümpelmann M., Wenzelburger R., Stolze H., Fietzek U., Pfister G., Elgar C.E., Timmer J., Deuschl G.:
  Is the rhythm of physiological tremor involved in cortico-cortical interactions ? , Movement Disorders 19, 2004, 458-465
  

• Schelter B., Winterhalder M., Hellwig B., Guschlbauer B., Lücking C.H., Timmer J.:
  Direct or Indirect ? Graphical models for neural oscillators.
  J. Physiol. 99, 2006, 37-46