Dr. Hua Tang
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abgelegt unter:
FDM-Seminar
Learning Genetic Architecture of Complex Traits Across Populations
| Was |
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| Wann |
29.06.2018 von 12:00 bis 13:00 |
| Wo | Ernst-Zermelo-Straße 1, Raum 404, 4. OG |
| Termin übernehmen |
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Genome-wide association studies (GWAS) have become a standard approach for identifying loci influencing complex traits. However, GWAS in non-European populations are hampered by limited sample sizes and are thus underpowered. We introduce an empirical Bayes approach, which improves the power of mapping trait loci relevant in minority populations through adaptively leveraging multi-ethnic evidence. Likewise, trans-ethnic information can improve genetic risk prediction of traits and diseases. I will discuss how these statistical approaches can be extended to integrate other types of biological knowledge.