Publications
- H. Feldwisch-Drentrup, M. Staniek, A. Schulze-Bonhage, J. Timmer, H. Dickten, C.E. Elger, B. Schelter, K. Lehnertz.
Identification of preseizure states in epilepsy: A data-driven approach for multichannel EEG recordings.
Frontiers in Computational Neuroscience 5, 2011, 32. - H. Feldwisch-Drentrup, A. Schulze-Bonhage, J. Timmer, B. Schelter.
Statistical validation of event predictors: A comparative study based on the field of seizure prediction.
Phys. Rev. E 83, 2011, 066704. - A. Schad, J. Timmer, M. Roth.
A unified approach to the helioseismic inversion problem of the solar meridional flow from global oscillations.
Astrophys. J. 734, 2011, 97. - L. Sommerlade, F. Amtage, O. Lapp, B. Hellwig, C.-H. LÃœcking, J. Timmer, B. Schelter.
On the estimation of the direction of information flow in networks of dynamical systems.
J. Neurosci. Meth. 196, 2011, 182-189. - Raue A, Kreutz C, Maiwald T, Klingmueller U, Timmer J.
Addressing Parameter Identifiability by Model-Based Experimentation
IET Systems Biology, 2011, 5(2), 120-130. - Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A, Raue A, Sticht C, Bohl S, Saile M, Möller P, Gretz N, Timmer J, Theis F, Lehmann WD, Lichter P and Klingmüller U.
Dynamic Mathematical Modeling of IL13-induced Signaling in Hodgkin and Primary Mediastinal B-cell Lymphoma Allows Prediction of Therapeutic Targets.
Cancer Research, 2011, 71(3), 1-12. - Bachmann J, Raue A, Schilling M, Bohm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmueller U.
Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.
Mol Syst Biol., 2011, 7, 516. -
Allignol A, Latouche A, Yan J, Fine JP.
A regression model for the conditional probability of a competing event: application to monoclonal gammopathy of unknown significance.
J R Stat Soc C-appl, 2011; 60: 135-142:
http://dx.doi.org/10.1111/j.1467-9876.2010.00729.x -
Allignol A, Schumacher M, Beyersmann J.
Estimating summary functionals in multistate models with an application to hospital infection data.
Computation Stat, 2011; 26: 181-197: http://dx.doi.org/10.1007/s00180-010-0200-x -
Allignol A, Schumacher M, Wanner C, Drechsler C, Beyersmann J.
Understanding competing risks: a simulation point of view.
Bmc Med Res Methodol, 2011; 11 (online): 86
(download: http://dx.doi.org/10.1186/1471-2288-11-86) -
Barnett AG, Beyersmann J, Allignol A, Rosenthal VD, Graves N, Wolkewitz M.
The time-dependent bias and its effect on extra length of stay due to nosocomial infection.
Value Health, 2011; 14: 381-386: http://dx.doi.org/10.1016/j.jval.2010.09.008 -
Beyersmann J, Wolkewitz M, Allignol A, Grambauer N, Schumacher M.
Application of multistate models in hospital epidemiology: Advances and challenges. Biometrical J, 2011; 53: 332-350: http://dx.doi.org/10.1002/bimj.201000146
- De Angelis G, Allignol A, Murthy A, Wolkewitz M, Beyersmann J, Safran E, Schrenzel J, Pittet D, Harbarth S.
Multistate modelling to estimate the excess length of stay associated with meticillin-resistant Staphylococcus aureus colonisation and infection in surgical patients.
J Hosp Infect, 2011; 78: 86-91: http://dx.doi.org/10.1016/j.jhin.2011.02.003 \ - Graves N, Barnett AG, Halton K, Crnich C, Cooper B, Beyersmann J, Wolkewitz M, Samore M, Harbarth S.
The Importance of Good Data, Analysis, and Interpretation for Showing the Economics of Reducing Healthcare-Associated Infection.
/Infection Control and Hospital Epidemiology/, 2011; 32: 927-928:
http://dx.doi.org/10.1086/661600 - Binder H., Porzelius C., Schumacher M.
An overview of techniques for linking high-dimensional molecular data to time-to-event endpoints by risk prediction models.
Biometrical Journal 53, 2011, 170-189. - Eugster M., Knaus J., Porzelius C., Schmidberger M., Vicedo E.
Hands-on tutorial for parallel computing with R.
Computational Statistics 26, 2011, 219-239. - Porzelius C., Johannes M., Binder H., Beißbarth T.
Leveraging external knowledge on molecular interactions in classification methods for risk prediction of patients.
Biometrical Journal 53, 2011, 190-201. - Porzelius C., Schumacher M., Binder H.
The benefit of data-based model complexity selection via prediction error curves in time-to-event data.
Computational Statistics 26, 2011, 293-302.
- Binder H, Porzelius C, Schumacher M.
An overview of techniques for linking high-dimensional molecular data to time-to-event endpoints by risk prediction models.
Biometrical Journal, 2011; 53: 170-189. - Porzelius C, Johannes M, Binder H, Beißbarth T.
Leveraging external knowledge on molecular interactions in classification methods for risk prediction of patients.
Biometrical Journal, 2011; 53: 190-201 - Porzelius C, Schumacher M, Binder H.
The benefit of data-based model complexity selection via prediction error curves in time-to-event data.
Computational Statistics, 2011; 26: 293-302 - Rücker G, Schwarzer G, Carpenter JR, Binder H, Schumacher M.
Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis. Biostatistics, 2011; 12: 122-142 - Schoop R, Beyersmann J, Schumacher M, Binder H.
Quantifying the predictive accuracy of time-to-event models in the presence of competing risks.
Biometrical Journal, 2011; 53: 88-112 - Bauer R, Gottfriedsen G-U, Binder H, Dobmeier M, Cording C, Hajak G, Spiessl H.
Burden of caregivers of patients with bipolar affective disorders.
American Journal of Orthopsychiatry, 2011; 81: 139-148.
- Schoop R, Schumacher M, Graf E.
Measures of prediction error for survival data with longitudinal covariates.
Biometrical J, 2011; 53: 275-293: http://dx.doi.org/10.1002/bimj.201000145
- Binder H, Sauerbrei W.
Adding local components to global functions for continuous covariates in multivariable regression modeling.
Statistics in Medicine, 2010; 29: 800-817. - Porzelius C, Schumacher M, Binder H.
A general, prediction error-based criterion for selecting model complexity for high-dimensional survival models.
Statistics in Medicine, 2010; 29: 830-838. - Porzelius C, Schumacher M, Binder H.
Sparse regression techniques in low-dimensional survival settings.
Statistics and Computing, 2010; 20:151-163.
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M. Ihle, H. Feldwisch-Drentrup, C.A. Teixeira, A. Witon, B. Schelter, J. Timmer, A. Schulze-Bonhage.
EPILEPSIAE - A European epilepsy database
Computer Methods and Programs in Biomedicine, in press. pdf -
H. Feldwisch-Drentrup, B. Schelter, M. Jachan, J. Nawrath, J. Timmer, A. Schulze-Bonhage
Joining the benefits: Combining epileptic seizures prediction methods.
Epilepsia, 51:1598-1606, 2010 pdf
- B. Schelter, H. Feldwisch-Drentrup, J. Timmer, J. Gotman, A. Schulze-Bonhage
A common strategy and database to compare the performance of seizure prediction algorithms.
Epilepsy & Behavior, 17:154—156, 2010 pdf
- D. Saur, B. Schelter, S. Schnell, D. Kratochvil, H. Küpper, P. Kellmeyer, D. Kümmerer, S. Klöppel, V. Glauche, R. Lange, W. Mader, D. Feess, J. Timmer, C. Weiller.
Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension.
Neuroimage 49, 2010, 3187-3197 - J. Nawrath, M.C. Romano, M. Thiel, I.Z. Kiss, M. Wickramasinghe, J. Timmer, J. Kurths, B. Schelter.
Distinguishing direct and indirect interactions in oscillatory networks with multiple time scales.
Phys. Rev. Lett. 104, 2010, 038701 - Raue A, Becker V, Klingmüller U and Timmer J.
Identifiability and Observability Analysis for Experimental Design in Non-Linear Dynamical Models.
Chaos, 2010, 20(4), 045105. - Becker V, Schilling M, Bachmann J, Baumann U, Raue A, Maiwald T, Timmer J and Klingmüller U.
Covering a broad dynamic range: information processing at the erythropoietin receptor.
Science, 2010, 328(5984), 1404-1408. - Zellmer S, Schmidt-Heck W, Bauer A, Meyer C, Lehmann T, Sparna T, Godoy P, Amin P, Schormann W, Bedawy E, Hammad S, Kern C, Kreutz C, Timmer J, Walz G, von Weizsäcker F, Thürmann PA, Dooley S, Merfort I, Guthke R, Hengstler JG, Gebhardt R.
The transcription factors ETF, E2F and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.
Hepatology , 2010, 52(6), 2127-2136. - Wolkewitz M, Allignol A, Schumacher M, Beyersmann J.
Two pitfalls in survival analyses of time-dependent exposure: a case study in a cohort of Oscar Nominees.
Am Stat, 2010; 64: 205-211: http://dx.doi.org/10.1198/tast.2010.08259 - Wolkewitz M, Beyersmann J, Schumacher M.
A note on statistical association and causality derived from epidemiological ICU data. Intens Care Med, 2010; 36: 549: http://dx.doi.org/10.1007/s00134-009-1721-z -
Grambauer N, Schumacher M, Dettenkofer M, Beyersmann J.
Incidence densities in a competing events analysis.
Am J Epidemiol. 2010 Nov 1;172(9):1077-84. Epub 2010 Sep 3. PubMed PMID: 20817786. -
Grambauer N, Schumacher M, Beyersmann J.
Proportional subdistribution hazards modeling offers a summary analysis, even if misspecified.
Stat Med. 2010 Mar 30;29(7-8):875-84. PubMed PMID: 20213713. -
Allignol A, Beyersmann J.
Software for fitting nonstandard proportional subdistribution hazards models. Biostatistics, 2010; 11: 674-675: http://dx.doi.org/10.1093/biostatistics/kxq018 -
Allignol A, Schumacher M, Beyersmann J.
A note on variance estimation of the Aalen-Johansen estimator of the cumulative incidence function in competing risks, with a view towards left-truncated data. Biometrical J, 2010; 52: 126-137: http://dx.doi.org/10.1002/bimj.200900039 -
Porzelius C., Schumacher M., Binder H.
A general, prediction error-based criterion for selecting model complexity for high-dimensional survival models.
Statistics in Medicine 29, 2010, 830-838. -
Porzelius C., Schumacher M., Binder H.
Sparse regression techniques in low-dimensional survival data settings.
Statistics and Computing 20, 2010, 151-163.
- Binder H, Sauerbrei W.
Adding local components to global functions for continuous covariates in multivariable regression modeling.
Statistics in Medicine, 2010; 29: 800-817. - Porzelius C, Schumacher M, Binder H.
A general, prediction error-based criterion for selecting model complexity for high-dimensional survival models.
Statistics in Medicine, 2010; 29: 830-838. - Porzelius C, Schumacher M, Binder H.
Sparse regression techniques in low-dimensional survival settings.
Statistics and Computing, 2010; 20:151-163.
- Sreseli RT, Binder H, Kuhn M, Digel W, Veelken H, Sienel W, Passlick B, Schumacher M, Martens UM, Zimmermann S.
Identification of a 17-protein signature in the serum of lung cancer patients.
Oncology Reports, 2010; 24:263-270 - De Angelis G, Murthy A, Beyersmann J, Harbarth S:
Estimating the impact of healthcare-associated infections on length of stay and
costs.
Clin Microbiol Infec, 2010; 16: 1729-1735 - Graves N, Harbarth S, Beyersmann J, Barnett A, Halton K, Cooper B:
Healthcare epidemiology: estimating the cost of health care associated infections: mind your p's and q's.
Clin Infect Dis, 2010; 50: 1017-1021 - Zahn D, Weidner G, Beyersmann J, Smits JMA, Deng MC, Kaczmarek I,
Meyer S, Reichenspurner H, Mehlhorn U, Wagner FM, Spaderna H:
Composite risk scores and depression as predictors of competing
waiting-list outcomes: the Waiting for a New Heart Study.
Transpl Int, 2010; 23: 1223-1232 - Zuschneid I, Rücker G, Schoop R, Beyersmann J, Schumacher M, Geffers
C, Rüden H, Gastmeier P:
Representativeness of the surveillance data in the intensive care unit component of the German Nosocomial Infections Surveillance System.
Infect Cont Hosp Ep, 2010; 31: 934-938
2009
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Functional diversity of R3 single-repeat genes in trichome development.Development 136, 2009, 1487-1496 pdf
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Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.Mol. Sys. Bio. 5, 2009, 256 pdf
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Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays.Laboratory Investigation 89, 2009, 385-397
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Effect of jump discontinuity for phase-randomized surrogate data testing.Int. J. Bif. Chaos 19, 2009, 403-408 pdf
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Assessing the strength of directed influences among neural signals using renormalized partial directed coherence.J. Neuroscience Methods 179, 2009, 121-130 pdf
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A novel approach for reliable microarray analysis of microdissected tumour cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens.J. Molecular Medicine 87, 2009, 211-224 pdf
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A longitudinal study of tremor frequencies in Parkinson's disease and essential tremor.Clinical Neurophysiology 120, 2009, 431-435 pdf
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Noisy signalling through promoter logic gates.Phys. Rev. E 79, 2009, 11923 pdf
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Systems biology: experimental design.FEBS Journal 276, 2009, 923-942 pdf
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Location-dependency of earthworm response to reduced tillage on sandy soil.Soil & Tillage Research 102, 2009, 55-66 pdf
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Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J, Klingmüller U.
Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions.
Mol Syst Biol. 2009;5:334.
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Raue A, Kreutz C, Maiwald T, Bachmann J, Schilling M, Klingmüller U, Timmer J.
Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood.
Bioinformatics. 2009 Aug 1;25(15):1923-1929. -
Bartholome K., Kreutz C., Timmer J.
Estimation of gene induction enables a relevance-based ranking of gene sets
J Comput Biol. 2009 Jul;16(7):959-67. -
Rumberger B, Kreutz C, Nickel C, Klein M, Lagoutte S, Teschner S, Timmer J, Gerke P, Walz G, Donauer J.
Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro.
Immunopharmacol Immunotoxicol. 2009 Mar 9:1-10
- Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
Modeling the effect of time-dependent exposure on intensive care unit mortality.
Intens Care Med, 2009; 35: 826-832: http://dx.doi.org/10.1007/s00134-009-1423-6 - Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
Efficient risk set sampling when a time-dependent exposure is present. Matching for time to exposure versus exposure density sampling.
Method Inform Med, 2009; 48: 438-443: http://dx.doi.org/10.3414/ME9241 - Knaus J., Porzelius C., Binder H., Schwarzer G.
Easier Parallel Computing in R with snowfall and sfCluster.
The R Journal 1, 2009, 54-59. - Porzelius C., Binder H., Schumacher M.
Parallelized prediction error estimation for evaluation of high-dimensional models.
Bioinformatics 25, 2009, 827-829.
- Binder H, Allignol A, Schumacher M, Beyersmann J.
Boosting for high-dimensional time-to-event data with competing risks.
Bioinformatics, 2009; 25: 890-896. - Binder, H, Graf E:
Brier scores.
In Kattan MW, editor, Encyclopedia of Medical Decision Making. SAGE Publications, 2009. - Binder H, Sauerbrei W.
Stability analysis of an additive spline model for respiratory health data using knot removal.
Journal of the Royal Statistical Society: Series C (Applied Statistics), 2009; 58:577-600. - Binder H, Schumacher M.
Incorporating pathway information into boosting estimation of high-dimensional risk prediction models.
BMC Bioinformatics, 2009; 10: 18. - Beyersmann J, Kneib T, Schumacher M, Gastmeier P:
Nosocomial infection, length of stay, and time\u2010dependent bias.
Infect Cont Hosp Ep, 2009; 30: 273-276 - Beyersmann J, Latouche A, Buchholz A, Schumacher M:
Simulating competing risks data in survival analysis.
Stat Med, 2009; 8: 956-971 - L. Sommerlade, M. Eichler, M. Jachan, K. Henschel, J.
Timmer, B. Schelter.
Estimating causal dependencies in networks of nonlinear
stochastic dynamical systems.
Phys. Rev. E 80, 2009, 051128 - L. Sommerlade, K. Henschel, J. Wohlmuth, M. Jachan, F.
Amtage, B. Hellwig, C.H. Lücking, J. Timmer, B. Schelter.
Time-variant estimation of directed influence during Parkinsonian tremor.
J. Physiol.103, 2009, 348-352
2008
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On the detection of direct directed information flow in fMRI.IEEE J. Sel. Topics in Signal Processing 2, 2008, 965-974 pdf
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Multivariate Analyis of dynamical processes: Point processes and time series.Europ. Phys. J. 165, 2008, 25-34 pdf
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A quantitative and dynamic model for plant stem cell regulation.PLoS One 3, 2008, e3553 pdf
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Cerebral dysautoregulation and the risk of ischemic events in occlusive carotid artery disease.J. Neurology 255, 2008, 195-199 pdf
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Cerebellar autoregulation dynamics in humans.J. Cerebral Blood Flow Metabolism 28 pdf
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A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves.
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Dynamical modeling and multi-experiment fitting with PottersWheel.
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Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients.Neuroscience Lett. 442, 2008, 195-199 pdf
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A spatial approach to soil-ecological experimentation at landscape scale.J. Plant Nutr. Soil Science 171, 2008, 339-343 pdf
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Cerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis.Cerebrovascular Diseases 26, 2008, 147-155 pdf
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Regulatory principles and systems analysis of bacterial chemotaxis.AT Automatisierungstechnik 56, 2008, 241-249
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Two-dimensional patterning by a trapping/depletion mechanism: The role of TTG1 and GL3 in Arabidopsis trichome formation.PloS Biology 6, 2008, e141 pdf
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A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway.
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Hybrid optimization method with general switching strategy for parameter estimation.BMC Systems Biology 2, 2008, 26 pdf
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Application of a multivariate seizure detection and prediction method to non-invasive and intracranial long-term EEG recordings.Clinical Neurophysiology 119, 2008, 197-211 pdf
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Allignol A, Beyersmann J, Schumacher M.
mvna: An R Package for the Nelson–Aalen Estimator in Multistate Models.
R News, 2008; 8: 48-50: http://CRAN.R-project.org/doc/Rnews -
Wolkewitz M, Dettenkofer M, Bertz H, Schumacher M, Huebner J.
Statistical epidemic modeling with hospital outbreak data.
Stat Med, 2008; 27: 6522-6531: http://dx.doi.org/10.1002/sim.3419
- Wolkewitz M, Vonberg RP, Grundmann H, Beyersmann J, Gastmeier P, Bärwolff S, Geffers C, Behnke M, Rüden H, Schumacher M.
Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models.
Crit Care, 2008; 12 (online): R44: http://dx.doi.org/10.1186/cc6852 - Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M.
Regression modelling in hospital epidemiology: a statistical note.
Crit Care, 2008; 12: 427: http://dx.doi.org/10.1186/cc6991
- Binder H, Sauerbrei W.
Increasing the usefulness of additive spline models by knot removal.
Computational Statistics & Data Analysis, 2008; 52: 5305-5318 - Binder H, Schumacher M.
Adapting prediction error estimates for biased complexity selection in high-dimensional bootstrap samples.
Statistical Applications in Genetics and Molecular Biology, 2008; 7: Article 12 - Binder H, Schumacher M.
Allowing for mandatory covariates in boosting estimation of sparse high-dimensional survival models.
BMC Bioinformatics, 2008; 9: 14 - Binder H, Schumacher M.
Comment on 'Network-constrained regularization and variable selection for analysis of genomic data'.
Bioinformatics, 2008; 24: 2566-2568 - Binder H, Tutz G: A comparison of methods for the fitting of generalized additive models. Statistics and Computing, 2008; 18: 87-99
- Landgrebe M, Binder H, Koller M, Eberl Y, Kleinjung T, Eichhammer P, Graf E, Hajak G, Langguth B.
Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius.
BMC Psychiatry, 2008; 8: 1-9 - Schoop R, Graf E, Schumacher M.
Quantifying the predictive performance of prognostic models for censored survival data with time-dependent covariates.
Biometrics, 2008; 64: 603-610 - Beyersmann J, Gastmeier P, Grundmann H, Bärwolff S, Geffers C, Behnke
M, Rüden H, Schumacher M:
Transmission-associated nosocomial infections: Prolongation of intensive care unit stay and risk factor analysis using multistate models
Am J Infect Control, 2008; 36: 98-103 - Beyersmann J, Schumacher M:
Time-dependent covariates in the proportional subdistribution hazards model for competing risks.
Biostatistics, 2008; 9: 765-776 - Beyersmann J, Schumacher M:
A note on nonparametric quantile inference for competing risks and more complex multistate models.
Biometrika, 2008; 95: 1006-1008
2007
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Dynamic pathway modeling - Feasibility analysis and optimal experimental design.Annals New York Acad. Sci.1115, 2007, 212-220 pdf
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Detecting coupling directions in multivariate oscillatory systems.Int. J. Bif. Chaos 17, 2007, 3735-3739 pdf
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Phase synchronization and coherence analysis: sensitivity and specificity.Int. J. Bif. Chaos 17, 2007, 3551-3556 pdf
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Control of plant organ size by KLUH/CYP78A5-dependent intracellular signalling.Developmental Cell 13, 2007, 843-856 pdf
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An error model for protein quantification.
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Data-dased identifiability analysis of nonlinear dynamical models.
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cDNA mircoarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain.Kidney Blood Pressure Res. 30, 2007, 377-378 pdf
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Data-based mathematical modeling of vectorial transport across double-transfected polarized cells.
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Preserved dynamic cerebral autoregulation in the middle cerebral artery among persons with migraine.Exp. Brain Res. 180, 2007, 517-523 pdf
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Testing for phase synchronization.Phys. Lett. A 366, 2007, 382-390 pdf
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Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting.IET Systems Biology 1, 2007, 78-88 pdf
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Microarray analysis reveals nfluence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.Life Sciences 80, 2007, 1608-1618 pdf
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Reconstructing gene-regulatory networks from time series, knock-out data, and prior knowledge.BMC Systems Biology 1, 2007, 11 pdf
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Seizure prediction: The impact of long prediction horizons.Epilepsy Research 73, 2007, 213-217 pdf
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Revealing direction of coupling between neuronal oscillators from time series: Phase dynamics modeling versus partial directed coherence.Chaos 17, 2007, 013111 pdf
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Genome-wide analysis of DNA copy number changes in CLL using high-density SNP arrays.Blood 109, 2007, 1202-1210 pdf
- Schumacher M, Wangler M, Wolkewitz M, Beyersmann J.
Attributable mortality due to nosocomial infections - A simple and useful application of multistate models.
/Method Inform Med/, 2007; 46: 595-600 - Sauerbrei W, Royston P, Binder H.
Selection of important variables and determination of functional form for continuous predictors in multivariable model building.
Statistics in Medicine, 2007; 26: 5512-5528 - Schumacher M, Binder H, Gerds TA.
Assessment of survival prediction models based on microarray data.
Bioinformatics, 2007; 23: 1768-1774 - Tutz G, Binder H.
Boosting ridge regression.
Computational Statistics & Data Analysis, 2007; 51: 6044-6059 - Beyersmann J:
A random time interval approach for analysing the impact
of a possible intermediate event on a terminal event.
Biometrical J, 2007; 49: 742-749 - Beyersmann J, Dettenkofer M, Bertz H, Schumacher M:
A competing risks analysis of bloodstream infection after stem-cell transplantation using subdistribution hazards and cause-specific hazards.
Stat Med, 2007; 26: 5360-5369 - Meyer E, Beyersmann J, Bertz H, Wenzler-Röttele S, Babikir R,
Schumacher M, Daschner FD, Rüden H, Dettenkofer M the ONKO-KISS Study
Group:
Risk factor analysis of blood stream infection and pneumonia in neutropenic patients after peripheral blood stem-cell transplantation.
Bone Marrow Transpl, 2007; 39: 173-178
2006
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WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.
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Do false predictions of seizure depend on the state of vigilance? A report from two seizure prediction methods and proposed remedies.Epilepsia 47, 2006, 2058-2070 pdf
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Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.IEE Proc. Systems Biology 153, 2006, 433-447 pdf
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Detection of directed information flow in multidimensional biosignals.Biomed. Tech. 51, 2006, 281-287 pdf
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Capillary physiology of human medulloblastoma - Impact on chemotherapy.Cancer 107, 2006, 2223-2227 pdf
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Oscillatory cerebral hemodynamics - the macro- vs. microvascular level.J. Neurol. Sci. 250, 2006, 103-109 pdf
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Comment on: "Performance of a seizure warning algorithm based on the dynamics of intracranial EEG".Epilepsy Res. 72, 2006, 80-81 pdf
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Spatio-temporal patient-individual assessment of synchronization changes for epileptic seizure prediction.Clin. Neurophys. 117, 2006, 2399-2413 pdf
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TGene profiling of polycystic kidneys.Nephrol. Dial. Transplant. 21, 2006, 1816-1824
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Parameter estimation in stochastic biochemical reactions.IEE Trans. Syst. Biol. 153, 2006, 168-178 pdf
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Sensitivity and specificity of coherence and phase synchronization analysis.Phys. Lett. A 356, 2006, 26-34 pdf
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Bistability and self-oscillations in cell cycle control.Int. J. Bif. Chaos 16, 2006, 1057-1066 pdf
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Testing for directed influences among neural signals using partial directed coherence.Journal of Neuroscience Methods 152, 2006, 210-219 pdf
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Analysis of single ion channel data incorporating time interval omission and sampling.J. Roy. Soc. Interface 3, 2006, 87-97 pdf
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Testing statistical significance of multivariate time series methods for epileptic seizure prediction.Chaos 16, 2006, 013108 pdf
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Spatial analysis of earthworm biodiversity at the regional scale.Agriculture, Ecosystems & Environment 112, 2006, 367-380 pdf
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Direct or Indirect ? Graphical models for neural oscillators.J. Physiol. 99, 2006, 37-46 pdf
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Symmetries in Lévy term structure modelsApplied Finance 9, 2006, 967-986
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Tutz G, Binder H.
Generalized additive modelling with implicit variable selection by likelihood based boosting.
Biometrics, 2006; 62: 961-971 -
Beyersmann J, Gastmeier P, Grundmann H, Bärwolff S, Geffers C, Behnke
M, Rüden H, Schumacher M:
Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection.
Infect Cont Hosp Ep, 2006; 27: 493-499 -
Rücker G, Schoop R, Beyersmann J, Schumacher M, Zuschneid I:
Are KISS data representative of German intensive care units? - Statistical
issues.
Method Inform Med, 2006; 45: 424-429 -
Wangler M, Beyersmann J, Schumacher M:
changeLOS: An R-package for change in length of hospital stay based on the Aalen-Johansen estimator
R News, 2006; 6: 31-35
2005
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Design principles of a bacterial signalling network.
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Quantitative data generation for systems biology - the impact of randomisation, calibrators and normalisers.IEE Proc. Systems Biology 152, 2005, 193-200 pdf
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Computational processing and error reduction strategies for standardized quantitative data in biological networks.
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Comparison of linear signal processing techniques to infer directed interactions in multivariate neural systems.Signal Processing 85, 2005, 2137-2160 pdf
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Mixing properties of the Rossler system and consequences for coherence and synchronization analysis.Phys. Rev. E 72, 2005, 026213 pdf
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Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations.Stroke 36, 2005, 1684-1689 pdf
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On studentising and blocklength selection for the bootstrap on time series.Biometrical Journal 47,, 2005, 346-357 pdf
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Structural stability analysis of a cell cycle control model.Comptes rendus de l'Acad. Bulg. Sci. 58, 2005, 19-24
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Estimating rate constants from single ion channel currents when the initial distribution is known.Eur. Biophys. J. 34 , 2005, 306-313 pdf
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Gene Expression Profiling in Polycythemia vera: Overexpression of transcription factor NF-E2.British Journal of Haematology 129, 2005, 138-150
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Capillary physiology and drug delivery in central nervous system lymphomas.Annals Neurology 57, 2005, 136-139 pdf
- Tutz G, Binder, H.
Localized classification.
Statistics and Computing, 2005; 15: 155-166
2004
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Variations in substitution rate in human and mouse genomesPhys. Rev. Lett. 93, 2004, 208102 pdf
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Phase synchronization from noisy univariate signalsPhys. Rev. Lett. 93 , 2004, 154103 pdf
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Bifurcation Analysis of a Cell Mitosis Control ModelJ. Theor. Appl. Mech. 34, 2004, 87-100.
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Dynamical Analysis of Cell Function Models.A ReviewJ. Theor. Appl. Mech. 34, 2004, 55-78.
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Constructing Dynamical Model of Cell Cycle ControlComptes Rendus de l'Acad. Bulg. Sci. 57, 2004, 15-22.
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Tempting long-memory - on the interpretation of DFA resultsNonlinear Processes in Geophysics 11, 2004, 495-503 pdf
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Incomplete forced expiration - estimating vital capacity by a mathematical methodRespiration 71, 2004, 353-359
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Tremor analysis in two normal cohortsClin. Neurophys. 115, 2004, 2151-2156 pdf
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Tests for cycling in a signalling pathwayJ. Roy. Stat. Soc. C: Applied Stat. 53, 2004, 557 - 568
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;Surrogate based hypothesis test without surrogatesInt. J. Bif. Chaos 14, 2004, 2107-2114 pdf
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Identificaton of rate constants and non-observable absorption spectra in nonlinear biochemical reaction dynamicsInt. J. Bif. Chaos 14, 2004, 2081-2092 pdf
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Parameter identification techniques for partial differential equationsInt. J. Bif. Chaos 14, 2004, 2053-2060, pdf
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Modelling the nonlinear dynamics of cellular signal transductionInt. J. Bif. Chaos 14, 2004, 2069-2079 pdf
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Nonlinear dynamical system identification from uncertain and incomplete measurementsInt. J. Bif. Chaos 14, 2004, 1905-1933 pdf
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Comparison of three nonlinear seizure prediction methods by means of the seizure prediction characteristicPhysica D 194, 2004, 357-368 pdf
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Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulationStroke 35, 2004, 1381-1387 pdf
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Is the rhythm of physiological tremor involved in cortico-cortical interactions?Movement Disorders 19, 2004, 458-465
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An open source protein gel documentation system for proteome analysesJ. Chem. Inf. Comp. Sci. 44, 2004, 168-169 pdf
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Aperiodic flow-induced oscillations of collapsible tubes: a critical reappraisalMedical Engineering & Physics 26, 2004, 201-214 pdf
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Data driven optimal filtering for phase and frequency of noisy oscillations: application to vortex flowmetering.Phys. Rev. E 69, 2004, 016216 pdf
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Detection of improper installation from the sensor signal of vortex flowmeters.Flow Measurement and Instrumentation 15, 2004, 29-35
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Tutz G, Binder H: Flexible modelling of discrete failure time including time-varying smooth effects. Statistics in Medicine, 2004; 23: 2445-2461
2003
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Simulation methods for optimal experimental design in systems biologySimulation: Trans. Soc. Modeling Computer Simulation 79, 2003, 717-725
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Estimation of time-delays in biological systemsAnnals Biomed. Eng. 31, 2003, 1423-1439
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Bilateral severe carotid artery stenosis or occlusion - cerebral autoregulation dynamics and collateral flow patternsActa Neurochirurgica 145, 2003, 1053-1060 pdf
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Non-parametric identification of non-linear oscillating systemsJ. Sound Vib. 267, 2003, 1157-1167
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How well can epileptic seizures be predicted? An evaluation of a nonlinear methodBrain 216, 2003, 2616-2626 pdf
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Expression profiling on chronically rejected transplant kidneys.Transplantation 76, 2003, 539-547. pdf
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Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index.Stroke 34, 2003, 2138-2244 pdf
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Real-time monitoring of ethene/1-hexene copolymerizations: Determination of catalyst activity, copolymer composition and copolymerization parametersPolymer 44, 2003, 6179-6186 pdf
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Normalization of DNA-mircoarray data by nonlinear correlation maximizationJ. Comp. Biol. 10, 2003, 751-761 pdf
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Dynamic cerebral autoregulation and collateral flow patterns in patients with severe carotid stenosis or occlusion.Ultrasound Med. Biol. 29, 2003, 1105-1113 pdf
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Dynamic synchronisation of central oscillators in essential tremorClinical Neurophysiology 114, 2003, 1462-1467 pdf
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A combined approach for the identification of continuous nonlinear systemsInt. J. Adaptive Control 17, 2003, 335-352
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The seizure prediction characteristic: A general framework to assess and compare seizure prediction methodsEpilepsy and Behavior 4, 2003, 318 - 325 pdf
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Asymptotic scaling laws for precision of parameter estimates in dynamical systemsPhys. Lett. A 310, 2003, 269-280 PostScript
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Detection of very low frequency oscillations of cerebral hemodynamics is influenced by data detrendingMed. & Biol. Eng. & Comp. 41, 2003, 1028-1033 pdf
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;Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by data-based modelingProc. Natl. Acad. Sci. 100, 2003, 1028-1033 pdf
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Transfer function analysis for clinical evaluation of dynamic of cerebral autoregulation - a comparison between spontaneous and respiratory-induced oscillationsPhysiolog. Measurement 24, 2003, 27-45.
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Dynamical modelling of measured time series from a Q-switched CO_2 laserChaos, Solitons & Fractals 17, 2003, 397-404
2002
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Comment on "Kullback-Leibler and renormalized entropies: Application to electroencephalograms of epileptic patients"Phys. Rev. E 66, 2002, 043902, PostScript
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Parameter estimation in nonlinear delayed feedback systems from noisy dataPhys. Lett. A 299, 2002, 513-521, pdf
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Fitting parameters in partial differential equations from partially observed noisy dataPhysica D 171, 2002, 1-7, PostScript
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Essential tremor and cerebellar dysfunction: Abnormal ballistic movementsJ. Neurology, Neurosurgery, Psychiatry 73, 2002, 400-405, pdf
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Analysis of phase resolved partial discharge patterns of voids based on a stochastic process approach.J. Physics D: Applied Physics 35, 2002, 1149-1163, gzipped PostScript
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Diagnosis of sleep apnea based on automatic analysis of nasal pressure and forced oscillation impedance.Am. J. Resp. Crit. Care Med. 165, 2002, 940-944
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Method Independent Effects in Testing for Detailed Balance in Ion Channels Gating.Biophys. J. 82, 2002, 2275-2276
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Parameter identification in a dynamical model of anaerobic waste water treatment processes.Math. Biosciences 177-178, 2002, 147-160
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Quantitative analysis of anaerobic wastewater treatment processes: identifiability and parameter estimation.Biotech. & Bioeng. 78, 2002, 89-103
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Dynamic annual indoor illuminance simulations based on one-hour and one-minute means of irradiance data.Solar Energy 72, 2002, 385-395
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Influence of distraction of attention and precision level of exerted force on beta range EEG-EMG synchronization during maintainted motor contraction task.Electroenceph. clin. Neurophys. 113, 2002, 124-131
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Corticomuscular coherence in the 6-15 Hz band. Does the central component of physiological tremor originate from the cortex?Exp. Brain. Res. 142, 2002, 32-40
2001
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Identifying physical preperties of a C02 laser by dynamical modeling of measured time series.Phys. Rev. E 64, 2001, 016222
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Variability of frequency and phase between antagonistic muscle pairs in pathological human tremors.Muscle & Nerve 24, 2001, 1365-1370
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Delay estimation for cortico-peripheral relations.J. Neuroscience Methods 111, 2001, 127-139
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Finite size properties of maximum likelihood estimators and likelihood ratio tests in Hidden Markov Models.Biometrical J. 43, 2001, 863-879
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Evaluation of impaired dynamic cerebral autoregulation by the Mueller manoeuvre.Clinical Physiology 21, 2001, 229-237
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Dynamic cerebral autoregulation testing as a diagnostic tool in patients with carotid artery stenosisNeurological Research 23, 2001, 55-63
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Analysis of forced expired volume signals using multiexponential functionsMedical & Biological Engineering & Computing 39, 2001, 190-194
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Electroencephalography reveals tremor-correlated cortical activity in patients with essential tremorThe Lancet 357, 2001, 519-523
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Model selection in non-tested Markov models for ion-channel gatingJ. Theo. Biol. 208, 2001, 439-450, gzipped PostScript
2000
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Cross-spectral analysis of tremor time seriesInt J Bif Chaos 10, 2000, 2595-2610, gzipped PostScript
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The effects of non-identifiability on testing for detailed balance in aggregated Markov models of ion-channel gatingBiophys. J. 79,2000, 2918-2924, PostScript
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Parametric, nonparametric and parametric modeling of a chaotic circuit time seriesPhys. Lett.A 274, 2000, 123-134, gzipped PostScript
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Detection of sleep apnea with the forced oscillation technique compared to the three polysomnographic signals.Respiration 67, 2000 518-525
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Detection of obstructive sleep apnea by analysis of phase angle using the forced oscillation signalRespiration Physiology123, 2000, 87-99
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What can be inferred from surrogate data testing?Phys. Rev. Lett. 85, 2000, 2647, PostScript
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Maximum approximate likelihood estimator for MA-filtered hidden Markov models.IEEE Transactions on Signal Processing 48, 2000, 1537-1547
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Parameter estimation in nonlinear stochastic differential equationsChaos, Solitons & Fractals 11, 2000 , 2571-2578, PostScript
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Estimating Parameters in Differential Equations with Application to Laser Datain D.S. Broomhead, E.A. Luchinskaya, P.V.E. McClintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the Lakes, American Institute of Physics, Woodbury, NY, USA, 2000, 617-623
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Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators?Chaos 10 , 2000, 278-288, gzipped PostScript
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Pathological tremors: Deterministic chaos or nonlinear stochastic oscillators?in D.S. Broomhead, E.A. Luchinskaya, P.V.E. McClintock and T. Mullin, ed., Stochaos: Stochastic and Chaotic Dynamics in the LakesAmerican Institute of Physics, Woodbury, NY, USA, 2000, 197-202, gzipped PostScript
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Electroencephalography reveals tremor-correlated cortical activity in patients with Parkinson's disease.Electroencephalography and Clinical Neurophysiology, 2000, 806-809
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Selecting relevant electrode positions for classification tasks based on the electro-encephalogramMedical & Biological Engineering & Computing 38 , 2000, 62-67
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Linear and nonlinear time series analysis of the black hole candidate Cygnus X-1Phys. Rev. E 61 , 2000, 1342-1352, gzipped PostScript
1999
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Assessing muscle stiffness from quiet stance in Parkinson's diseaseMuscle & Nerve 22, 1999, 635-639
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Amplitude equations from spatiotemporal binary-fluid convection dataPhys. Rev. Lett. 83, 3422-3425 (1999).
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Equations of motion from chaotic data: A driven optical fiber ring resonatorPhysics Letters A 256, 47-54 (1999).
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Reconstruction of nonlinear time delay models fromoptical dataChaos, Solitons and Fractals 10, 805-809 (1999).
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Estimating rate constants in Hidden Markov Models by the EM algorithmIEEE Trans. Signal Proc. 47, 1999, 226-228
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On the irregular behaviour of the variable star R Scuti.Monthly Notices Royal Astronomical Society 303 , 1999, 297-300
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A test for a difference between spectral peak frequenciesComp Stat Data Analysis 30 , 1999, 45-55, gzipped PostScript
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Involvement of cranial muscles in orthostatic tremorAnn. Neur. 45 , 1999, 384-388
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Parkinsonian and essential tremor: Different entities or different manifestations of the same disorderAdvances in Neurology 80, 1999, 335-339
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A software for recording and analysis of human tremorComputer Methods and Programs in Biomedicine 60 , 1999, 65-77, gzipped PostScript
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Early detection of upper airway obstructions by analysis of acoustical respiratory input impedanceBiological Cybernetics 81, 1999, 25-37
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Classical conditioning of the electrically elicited blink reflex in humans: A new method of data analysisJ. Neuroscience Methods 89 , 1999, 133-140
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On identification of sodium channel gating schemes using moving-average filtered hidden Markov modelsEurop. Biophys. J. 28 , 1999, 605-609, gzipped PostScript
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Estimating rate constants in aggregated Markov models of ion channel gating with loops and with with nearly equal dwell timesProc. Roy. Soc. B 266 , 1999, 1919-1926, gzipped PostScript
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Side-to-side correlation of muscle activity in physiological and pathological human tremorsElectroencephalography and Clinical Neurophysiology 110 , 1999, 1774-1783
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The Effects of Stochastic Galvanic Vestibular Stimulation on Human Postural SwayExp. Brain Res. 124, 1999, 273-80
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The Dynamics of Quasistatic Posture ControlHuman Movement Science 18, 1999, 725-740
1998
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The role of simulation in modelling spatially correlated dataEnvironmetrics, 9, 175-196, 1998
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Spatio-temporal modelling for the annual egg production method of stock assessment using generalised additive modelsCanadian Journal of Fisheries and Aquatic Sciences. 55, 2608-2621, 1998
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Test for nonlinear dynamical behavior in symbol sequencesPhysical Review E 58, 1155-1158 (1998).
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Identification of continuous, spatiotemporal systemsPhysical Review E 57, 2820-2823 (1998).
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Nichtlineare statistische Methoden zur DatenanalyseDissertation im Fachgebiet Physik-Nichtlineare Dynamik
Eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät der Universität Potsdam, Mai 1998. -
Central mechanisms in human enhanced physiological tremorNeuroscience Letters 241, 1998, 135-138, gzipped PostScript
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Detecting multimodality in Saccadic reaction time distributions in gap and overlap tasksBiolog. Cybern. 78 , 1998, 293-305
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Cross-spectral analysis of physiological tremor and muscle activity. I: Theory and application to unsynchronized EMGBiolog. Cybern. 78 , 1998, 349-357, gzipped PostScript
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Cross-spectral analysis of physiological tremor and muscle activity. II: Application to synchronized EMGBiolog. Cybern. 78 , 1998, 359-368, gzipped PostScript
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Numerical methods for the determination of calcium release from calcium transients in muscle dataBiophys. J. 74 , 1998, 1694-1706, gzipped PostScript
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Estimating parameters in nonlinear differential equations with application to physiological datain: G. Osipenko, ed., Differential equations and applications, 1998, 23-33
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Estimating parameters in nonlinear differential equations with application to Q-switched lasersTechnische Anwendungen von Erkenntnissen der Nichtlinearen Dynamik, 1998, 311-314
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The power of surrogate data testing with respect to non-stationarityPRE 58 , 1998, 5153-5156, gzipped PostScript
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Quantitative analysis by renormalized entropy of invasive electroencephalograph recordings in focal epilepsyPRE 58 , 1998, 4859-4864, zipped PostScripts
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Modeling noisy time series: Physiological tremorInt. J. Bif. Chaos 8 , 1998, 1505-1516, gzipped PostScript
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Evaluation of forced oscillation technique for early detection of airway obstruction in sleep apnea: a model studyTech. Health Care 6 , 1998, 245-257
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Human balance out of equilibrium: Nonequilibrium statistical mechanics in posture controlPhys. Rev. Lett. 80, 1998, 413-416
1997
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Model selection: An integral part of inferenceBiometrics, 53, 603-618, 1997.
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Reconstruction of nonlinear time delay models from data by the use of optimal transformationsPhysics Letters A 234, 336-344 (1997).
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Solar Variability: Simple Models and Proxy DataG Cini Castagnoli (Ed.), Proceedings of the International School of Physics ``Enrico Fermi'', Varenna (1997).
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Analysis of multichannel patch clamp recordings by Hidden Markov ModelsBiometrics 53, 1997, 870-884
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Testing the Markov condition in ion channel recordingsPhys. Rev. E 55, 1997, 3306-3310
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The Seyfert Galaxy NGC 6814 -- a highly variable X-ray sourceAstronomy and Astrophysics 322, 1997, 747-750
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Saccadic reaction times: a statistical analysis of multimodal distributionsVision Research 37, 1997, 2119-2131
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Analyzing X-ray variability by Linear State Space ModelsAstronomy and Astrophysics, SS 124, 1997, 589-596, gzipped PostScript
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Confidence regions for spectral peak frequenciesBiometrical J. 39, 1997, 849-861, gzipped PostScript
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Modeling volatility using state space modelsInt. J. Neur. Syst. 8 , 1997, 385-398, gzipped PostScript
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Using Optimized Time-Frequency Representations for Acoustic Quality Control of MotorsActa Acoustica 83, 1997, 1053-1064, PostScript
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Optimal weighed Bayesian design applied to dose-response-curve analysisCommunications in Statistics - Theory and Methods 26, 1997, 2879-2903
1996
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An autologistic model for the spatial distribution of wildlife.Journal of Applied Ecology, 33, 339-347, 1996.
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Regression methods with spatially referenced data.Aspects of Applied Biology, 46, 67-74, 1996.
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Reconstruction of grand minima of solar activity from radiocarbon dataJournal of Geophysical Research 101, 15,637-15,643 (1996).
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Clinical neurophysiology of tremor with relation to clinical diagnosis and pathophysiologyJournal of Clinical Neurophysiology, 13, 1996, 110
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Both Adenosine A1- and A2-receptors are required to stimulate microglial proliferationNeurochemistry International, 29, 1996, 37-42
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Effects of light and chronotherapie on human circadian rhythm in delayed sleep phase syndrom (DSPS): cytokines, cortisol, growth hormone and the sleep-wake cycleBiological Psychiatry 40, 1996, 794-797
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Quantitative analysis of tremor time seriesElectroencephalography and Clinical Neurophysiology 101, 1996, 461-468
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Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute Major Depressive episodesPsychiatry Research 65, 1996, 45-61
1995
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Optimum time-frequency representations for the classification and detection of signalsAppl. Sig. Proc.3 1995, 124-143
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Hyperbolic Distributions in FinanceBernouilli 1/1995, S. 281-299 PostScript
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Some considerations on the Interpretation of Event-Related-PotentialsJournal of Neural Transmission 99, 1995, 103-129
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On generating power law noiseAstronomy and Astrophysics, 300, 1995, 707
1994
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Interleukin-6 Serum Levels in Healthy Persons correspond to the Sleep-Wake-CycleClinical Investigator 72, 1994, 312
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Failure of Dimension Analysis in a simple Five-Dimensional SystemPhys. Rev. E 50, 1994, 1770-1780
1993
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Characteristics of Hand Tremor Time SeriesBiol. Cybern. 70, 1993, 75-80
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Cytokine Production during Sleep and Wakefulness and its Relationship to Cortisol in Healthy HumansNeuropsychobiology 28, 1993, 9-16
1992
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Analysing the dynamics of hand tremor time seriesBiol. Cybern. 66, 1992, 479-484